BRD-A18419789_Etoposide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-A18419789_Etoposide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF3 activating transcription factor 3
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CENPU centromere protein U
CLU clusterin
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT4 DNA-damage-inducible transcript 4
DES desmin
DSG3 desmoglein 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FEN1 flap structure-specific endonuclease 1
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPC4 glypican 4
HBEGF heparin-binding EGF-like growth factor
HPSE heparanase
HSPA4L heat shock 70kDa protein 4-like
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
INPP1 inositol polyphosphate-1-phosphatase
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0101 KIAA0101
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LMO4 LIM domain only 4
LPAR2 lysophosphatidic acid receptor 2
LY6D lymphocyte antigen 6 complex, locus D
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
NAMPT nicotinamide phosphoribosyltransferase
NCF2 neutrophil cytosolic factor 2
PCNA proliferating cell nuclear antigen
PKP1 plakophilin 1
PLEK2 pleckstrin 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX2 peroxiredoxin 2
RALGDS ral guanine nucleotide dissociation stimulator
REG1A regenerating islet-derived 1 alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RNF19B ring finger protein 19B
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPRR1B small proline-rich protein 1B
THBD thrombomodulin
TIGAR TP53 induced glycolysis regulatory phosphatase
TPD52L1 tumor protein D52-like 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM29 tripartite motif containing 29
TSKU tsukushi, small leucine rich proteoglycan
UGCG UDP-glucose ceramide glucosyltransferase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK AHNAK nucleoprotein
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNF cyclin F
CD302 CD302 molecule
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CXCL12 chemokine (C-X-C motif) ligand 12
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCN decorin
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
FN1 fibronectin 1
GOLGA8A golgin A8 family, member A
GTSE1 G-2 and S-phase expressed 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA5 homeobox A5
HSPA8 heat shock 70kDa protein 8
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL1R1 interleukin 1 receptor, type I
IL6ST interleukin 6 signal transducer
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIF2C kinesin family member 2C
KLF6 Kruppel-like factor 6
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LRRC41 leucine rich repeat containing 41
LUM lumican
MAN1A1 mannosidase, alpha, class 1A, member 1
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MDFIC MyoD family inhibitor domain containing
MKI67 marker of proliferation Ki-67
MT1F metallothionein 1F
NCAPD2 non-SMC condensin I complex, subunit D2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRP1 neuropilin 1
PLK1 polo-like kinase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PSRC1 proline/serine-rich coiled-coil 1
PURA purine-rich element binding protein A
QPRT quinolinate phosphoribosyltransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SKAP2 src kinase associated phosphoprotein 2
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SMC4 structural maintenance of chromosomes 4
TBCB tubulin folding cofactor B
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican