BRD-A18419789_Etoposide_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

285 genes differentially expressed following the BRD-A18419789_Etoposide_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADCK3 aarF domain containing kinase 3
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AREG amphiregulin
ASCC3 activating signal cointegrator 1 complex subunit 3
BAX BCL2-associated X protein
BEX4 brain expressed, X-linked 4
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CLCA2 chloride channel accessory 2
CLCA4 chloride channel accessory 4
CLEC2B C-type lectin domain family 2, member B
COL15A1 collagen, type XV, alpha 1
COL17A1 collagen, type XVII, alpha 1
COL4A5 collagen, type IV, alpha 5
CPD carboxypeptidase D
CSTA cystatin A (stefin A)
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R1 cytochrome b5 reductase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DGKA diacylglycerol kinase, alpha 80kDa
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSG3 desmoglein 3
DSP desmoplakin
DST dystonin
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFR epidermal growth factor receptor
EPHA2 EPH receptor A2
EPS8L2 EPS8-like 2
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FCGBP Fc fragment of IgG binding protein
FDXR ferredoxin reductase
FGFBP1 fibroblast growth factor binding protein 1
FXYD3 FXYD domain containing ion transport regulator 3
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GALE UDP-galactose-4-epimerase
GDF15 growth differentiation factor 15
GGT1 gamma-glutamyltransferase 1
GOLGA8B golgin A8 family, member B
GPC1 glypican 1
GPR87 G protein-coupled receptor 87
GSN gelsolin
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGFBP6 insulin-like growth factor binding protein 6
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
INPP1 inositol polyphosphate-1-phosphatase
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB4 integrin, beta 4
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF5 Kruppel-like factor 5 (intestinal)
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LY6D lymphocyte antigen 6 complex, locus D
LY96 lymphocyte antigen 96
MAPK13 mitogen-activated protein kinase 13
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
NPEPL1 aminopeptidase-like 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PERP PERP, TP53 apoptosis effector
PHLDA3 pleckstrin homology-like domain, family A, member 3
PKP1 plakophilin 1
PLAU plasminogen activator, urokinase
PLTP phospholipid transfer protein
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPL periplakin
PRKCD protein kinase C, delta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RAB38 RAB38, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RBM47 RNA binding motif protein 47
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RIOK3 RIO kinase 3
RPS27L ribosomal protein S27-like
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SDC4 syndecan 4
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SFN stratifin
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
STAB1 stabilin 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
THBD thrombomodulin
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53I3 tumor protein p53 inducible protein 3
TP63 tumor protein p63
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
WARS tryptophanyl-tRNA synthetase
XPC xeroderma pigmentosum, complementation group C
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG6 adhesion G protein-coupled receptor G6
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMD1 adenosylmethionine decarboxylase 1
ANXA6 annexin A6
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BEX1 brain expressed, X-linked 1
BGN biglycan
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C4BPA complement component 4 binding protein, alpha
CALR calreticulin
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
COL5A1 collagen, type V, alpha 1
COL9A3 collagen, type IX, alpha 3
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DENND5A DENN/MADD domain containing 5A
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNTT DNA nucleotidylexotransferase
DPYSL2 dihydropyrimidinase-like 2
ECT2 epithelial cell transforming 2
EPHB2 EPH receptor B2
FAM64A family with sequence similarity 64, member A
FBXO5 F-box protein 5
FOXM1 forkhead box M1
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GDI2 GDP dissociation inhibitor 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPC3 glypican 3
GRB14 growth factor receptor-bound protein 14
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOMER2 homer scaffolding protein 2
HOXA10 homeobox A10
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGFBP1 insulin-like growth factor binding protein 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LEPR leptin receptor
LMNB1 lamin B1
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MBNL1 muscleblind-like splicing regulator 1
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRAME preferentially expressed antigen in melanoma
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTTG1 pituitary tumor-transforming 1
QPRT quinolinate phosphoribosyltransferase
RACGAP1 Rac GTPase activating protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPC25 SPC25, NDC80 kinetochore complex component
STAG2 stromal antigen 2
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TPX2 TPX2, microtubule-associated
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VCAM1 vascular cell adhesion molecule 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon