BRD-A18419789_Etoposide_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

274 genes differentially expressed following the BRD-A18419789_Etoposide_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL5 acyl-CoA synthetase long-chain family member 5
AMOTL2 angiomotin like 2
BLCAP bladder cancer associated protein
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CCNG2 cyclin G2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CLU clusterin
CPM carboxypeptidase M
CRYAB crystallin, alpha B
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNASE1L1 deoxyribonuclease I-like 1
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EPHA2 EPH receptor A2
EPS8L2 EPS8-like 2
FADS3 fatty acid desaturase 3
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FGG fibrinogen gamma chain
GAA glucosidase, alpha; acid
GBE1 glucan (1,4-alpha-), branching enzyme 1
GSN gelsolin
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGFBP6 insulin-like growth factor binding protein 6
INPP1 inositol polyphosphate-1-phosphatase
ISYNA1 inositol-3-phosphate synthase 1
KIZ kizuna centrosomal protein
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
NAV2 neuron navigator 2
NRCAM neuronal cell adhesion molecule
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPL periplakin
PRKX protein kinase, X-linked
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLFN12 schlafen family member 12
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STOM stomatin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TP53I3 tumor protein p53 inducible protein 3
TP53TG1 TP53 target 1 (non-protein coding)
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TRIM38 tripartite motif containing 38
TST thiosulfate sulfurtransferase (rhodanese)
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF185 zinc finger protein 185 (LIM domain)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALU calumenin
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHL1 cell adhesion molecule L1-like
CIT citron rho-interacting serine/threonine kinase
CKLF chemokine-like factor
CKS1B CDC28 protein kinase regulatory subunit 1B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EIF5A eukaryotic translation initiation factor 5A
EMP2 epithelial membrane protein 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FBLN5 fibulin 5
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
FRZB frizzled-related protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H1FX H1 histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
INHBA inhibin, beta A
ISLR immunoglobulin superfamily containing leucine-rich repeat
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KLF2 Kruppel-like factor 2
KNTC1 kinetochore associated 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MSH6 mutS homolog 6
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NASP nuclear autoantigenic sperm protein (histone-binding)
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP43 nucleoporin 43kDa
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
ORC6 origin recognition complex, subunit 6
PARP2 poly (ADP-ribose) polymerase 2
PARPBP PARP1 binding protein
PBK PDZ binding kinase
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PROM1 prominin 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRSS2 protease, serine, 2 (trypsin 2)
PXMP2 peroxisomal membrane protein 2, 22kDa
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RNF167 ring finger protein 167
RPA2 replication protein A2, 32kDa
RPL39L ribosomal protein L39-like
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SHCBP1 SHC SH2-domain binding protein 1
SKA1 spindle and kinetochore associated complex subunit 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMC4 structural maintenance of chromosomes 4
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
STEAP1 six transmembrane epithelial antigen of the prostate 1
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TFRC transferrin receptor
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TROAP trophinin associated protein
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZHX2 zinc fingers and homeoboxes 2
ZWILCH zwilch kinetochore protein