BRD-A18419789_Etoposide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

311 genes differentially expressed following the BRD-A18419789_Etoposide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADCY2 adenylate cyclase 2 (brain)
ADM adrenomedullin
ALOX15B arachidonate 15-lipoxygenase, type B
ANOS1 anosmin 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C3 complement component 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CD83 CD83 molecule
CH25H cholesterol 25-hydroxylase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTGF connective tissue growth factor
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN1 endothelin 1
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPHA4 EPH receptor A4
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IL1B interleukin 1, beta
IL32 interleukin 32
IL6 interleukin 6
INHBA inhibin, beta A
INHBB inhibin, beta B
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
LAMC2 laminin, gamma 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIF leukemia inhibitory factor
LIPG lipase, endothelial
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MT1E metallothionein 1E
MT1G metallothionein 1G
NAMPT nicotinamide phosphoribosyltransferase
NCF2 neutrophil cytosolic factor 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NKX3-1 NK3 homeobox 1
NOTCH1 notch 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
OPTN optineurin
ORM1 orosomucoid 1
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLAU plasminogen activator, urokinase
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RRAD Ras-related associated with diabetes
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SDC4 syndecan 4
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SESN1 sestrin 1
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STAR steroidogenic acute regulatory protein
TFRC transferrin receptor
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TOB1 transducer of ERBB2, 1
TRAF1 TNF receptor-associated factor 1
TRIM22 tripartite motif containing 22
TSC22D1 TSC22 domain family, member 1
TXNL4B thioredoxin-like 4B
VCAM1 vascular cell adhesion molecule 1
VCPKMT valosin containing protein lysine (K) methyltransferase
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BPHL biphenyl hydrolase-like (serine hydrolase)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CBX1 chromobox homolog 1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DEFB1 defensin, beta 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
ECT2 epithelial cell transforming 2
EPHA3 EPH receptor A3
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM3C family with sequence similarity 3, member C
FAM64A family with sequence similarity 64, member A
FOXD1 forkhead box D1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPSM2 G-protein signaling modulator 2
GTSE1 G-2 and S-phase expressed 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLTF helicase-like transcription factor
HMGA2 high mobility group AT-hook 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KANK2 KN motif and ankyrin repeat domains 2
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAP1B microtubule-associated protein 1B
MBNL1 muscleblind-like splicing regulator 1
MKI67 marker of proliferation Ki-67
NEK2 NIMA-related kinase 2
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PBK PDZ binding kinase
PDS5A PDS5 cohesin associated factor A
PEBP1 phosphatidylethanolamine binding protein 1
PFN2 profilin 2
PITX2 paired-like homeodomain 2
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PROM1 prominin 1
PSCA prostate stem cell antigen
PSPH phosphoserine phosphatase
PSRC1 proline/serine-rich coiled-coil 1
QPCT glutaminyl-peptide cyclotransferase
RACGAP1 Rac GTPase activating protein 1
RBM47 RNA binding motif protein 47
S100A7 S100 calcium binding protein A7
SHCBP1 SHC SH2-domain binding protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D16 TBC1 domain family, member 16
TBL1X transducin (beta)-like 1X-linked
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM4 tropomyosin 4
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TUBB tubulin, beta class I
TUSC3 tumor suppressor candidate 3
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta