BRD-A18328003_GDC-0980_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

252 genes differentially expressed following the BRD-A18328003_GDC-0980_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANXA11 annexin A11
ANXA4 annexin A4
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CCNG1 cyclin G1
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CIRBP cold inducible RNA binding protein
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CST3 cystatin C
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DAPK1 death-associated protein kinase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DRAM1 DNA-damage regulated autophagy modulator 1
EFNA1 ephrin-A1
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAXDC2 fatty acid hydroxylase domain containing 2
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HEATR1 HEAT repeat containing 1
HIST1H2AC histone cluster 1, H2ac
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KAT6B K(lysine) acetyltransferase 6B
KDM3A lysine (K)-specific demethylase 3A
KIAA0355 KIAA0355
KIAA1033 KIAA1033
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LCN2 lipocalin 2
LOC100272216 uncharacterized LOC100272216
LTA4H leukotriene A4 hydrolase
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
MLPH melanophilin
MSLN mesothelin
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYLIP myosin regulatory light chain interacting protein
NAP1L1 nucleosome assembly protein 1-like 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NOTCH2NL notch 2 N-terminal like
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFC platelet derived growth factor C
PERP PERP, TP53 apoptosis effector
PFDN5 prefoldin subunit 5
PHF20 PHD finger protein 20
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCH protein kinase C, eta
PRSS8 protease, serine, 8
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QARS glutaminyl-tRNA synthetase
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RGS10 regulator of G-protein signaling 10
RPL14 ribosomal protein L14
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPS14P3 ribosomal protein S14 pseudogene 3
RPS27L ribosomal protein S27-like
RSL24D1 ribosomal L24 domain containing 1
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SECISBP2L SECIS binding protein 2-like
SH3YL1 SH3 and SYLF domain containing 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SPDEF SAM pointed domain containing ETS transcription factor
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SVIL supervillin
SYF2 SYF2 pre-mRNA-splicing factor
SYT1 synaptotagmin I
SYT17 synaptotagmin XVII
TANK TRAF family member-associated NFKB activator
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM30B transmembrane protein 30B
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VIM vimentin
WDR45 WD repeat domain 45
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
AKIRIN1 akirin 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALG8 ALG8, alpha-1,3-glucosyltransferase
ARPC5L actin related protein 2/3 complex, subunit 5-like
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND3 cyclin D3
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CKLF chemokine-like factor
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HACD3 3-hydroxyacyl-CoA dehydratase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LBR lamin B receptor
LIPG lipase, endothelial
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC59 leucine rich repeat containing 59
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MPZL2 myelin protein zero-like 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPY1R neuropeptide Y receptor Y1
PARP2 poly (ADP-ribose) polymerase 2
PDZK1 PDZ domain containing 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POU2AF1 POU class 2 associating factor 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35B1 solute carrier family 35, member B1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPX2 TPX2, microtubule-associated
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein