BRD-A18328003_GDC-0980_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

295 genes differentially expressed following the BRD-A18328003_GDC-0980_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AKAP9 A kinase (PRKA) anchor protein 9
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD36B ankyrin repeat domain 36B
ANXA11 annexin A11
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTF3 basic transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIRBP cold inducible RNA binding protein
CLDN4 claudin 4
CPD carboxypeptidase D
CREBL2 cAMP responsive element binding protein-like 2
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CTSL cathepsin L
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3L eukaryotic translation initiation factor 3, subunit L
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPCAM epithelial cell adhesion molecule
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
EXPH5 exophilin 5
EYA2 EYA transcriptional coactivator and phosphatase 2
FAS Fas cell surface death receptor
FAXDC2 fatty acid hydroxylase domain containing 2
FOXN3 forkhead box N3
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAT6B K(lysine) acetyltransferase 6B
KDM3A lysine (K)-specific demethylase 3A
KIAA0430 KIAA0430
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
LAMB2 laminin, beta 2 (laminin S)
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
LTA4H leukotriene A4 hydrolase
LXN latexin
MACROD1 MACRO domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
MLPH melanophilin
MTUS1 microtubule associated tumor suppressor 1
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MVP major vault protein
MYLIP myosin regulatory light chain interacting protein
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NCK2 NCK adaptor protein 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NOTCH2NL notch 2 N-terminal like
NPIPB3 nuclear pore complex interacting protein family, member B3
OBSL1 obscurin-like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBX1 pre-B-cell leukemia homeobox 1
PCM1 pericentriolar material 1
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PHF3 PHD finger protein 3
PLAT plasminogen activator, tissue
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PSCA prostate stem cell antigen
PTPN12 protein tyrosine phosphatase, non-receptor type 12
QARS glutaminyl-tRNA synthetase
RAB13 RAB13, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RPL14 ribosomal protein L14
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RSL1D1 ribosomal L1 domain containing 1
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAMP1 secretory carrier membrane protein 1
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SECISBP2L SECIS binding protein 2-like
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC38A2 solute carrier family 38, member 2
SLC44A4 solute carrier family 44, member 4
SMAD3 SMAD family member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
STC1 stanniocalcin 1
STXBP2 syntaxin binding protein 2
SYT17 synaptotagmin XVII
TFPI2 tissue factor pathway inhibitor 2
TNNT1 troponin T type 1 (skeletal, slow)
TOM1L1 target of myb1 (chicken)-like 1
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
UBXN1 UBX domain protein 1
VEGFA vascular endothelial growth factor A
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
C20ORF24 chromosome 20 open reading frame 24
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND2 cyclin D2
CCND3 cyclin D3
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHRDL1 chordin-like 1
CKLF chemokine-like factor
CKS2 CDC28 protein kinase regulatory subunit 2
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYB561 cytochrome b561
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4E eukaryotic translation initiation factor 4E
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FRZB frizzled-related protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GNAS GNAS complex locus
GPC3 glypican 3
GPX3 glutathione peroxidase 3
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H4C histone cluster 1, H4c
HMGB3 high mobility group box 3
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
IFRD2 interferon-related developmental regulator 2
IFT57 intraflagellar transport 57
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LBR lamin B receptor
LIPG lipase, endothelial
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LPAR6 lysophosphatidic acid receptor 6
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC59 leucine rich repeat containing 59
LTB lymphotoxin beta (TNF superfamily, member 3)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MPZL1 myelin protein zero-like 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRKCB protein kinase C, beta
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RANBP1 RAN binding protein 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SCRG1 stimulator of chondrogenesis 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SRM spermidine synthase
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN2 stathmin 2
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TMEM45A transmembrane protein 45A
TPX2 TPX2, microtubule-associated
TRAPPC3 trafficking protein particle complex 3
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
VSNL1 visinin-like 1
ZWINT ZW10 interacting kinetochore protein