BRD-A18328003_GDC-0980_SKBR3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-A18328003_GDC-0980_SKBR3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP9 A kinase (PRKA) anchor protein 9
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFD complement factor D (adipsin)
CLEC2B C-type lectin domain family 2, member B
CLMN calmin (calponin-like, transmembrane)
COBL cordon-bleu WH2 repeat protein
CST1 cystatin SN
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEPTOR DEP domain containing MTOR-interacting protein
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB4 erb-b2 receptor tyrosine kinase 4
FST follistatin
FZD5 frizzled class receptor 5
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GSE1 Gse1 coiled-coil protein
HNMT histamine N-methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
JARID2 jumonji, AT rich interactive domain 2
KDM5A lysine (K)-specific demethylase 5A
KLHDC2 kelch domain containing 2
LAMP2 lysosomal-associated membrane protein 2
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLPH melanophilin
NBPF10 neuroblastoma breakpoint family, member 10
OBSL1 obscurin-like 1
PALLD palladin, cytoskeletal associated protein
PDCD6 programmed cell death 6
PNMA2 paraneoplastic Ma antigen 2
PRSS8 protease, serine, 8
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3BP4 SH3-domain binding protein 4
SLC22A18 solute carrier family 22, member 18
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SYNJ2 synaptojanin 2
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRIM2 tripartite motif containing 2
VAV3 vav 3 guanine nucleotide exchange factor
VEGFC vascular endothelial growth factor C
WASL Wiskott-Aldrich syndrome-like

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ANXA2 annexin A2
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBP emopamil binding protein (sterol isomerase)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGFR3 fibroblast growth factor receptor 3
GTSE1 G-2 and S-phase expressed 1
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IL32 interleukin 32
IL7R interleukin 7 receptor
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LBR lamin B receptor
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PELI1 pellino E3 ubiquitin protein ligase 1
PFN2 profilin 2
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PTTG1 pituitary tumor-transforming 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A2 S100 calcium binding protein A2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBI transforming growth factor, beta-induced, 68kDa
TPX2 TPX2, microtubule-associated
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)