BRD-A18328003_GDC-0980_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

294 genes differentially expressed following the BRD-A18328003_GDC-0980_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACADVL acyl-CoA dehydrogenase, very long chain
ACOX2 acyl-CoA oxidase 2, branched chain
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMOTL2 angiomotin like 2
ANG angiogenin, ribonuclease, RNase A family, 5
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
ASMTL acetylserotonin O-methyltransferase-like
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C14ORF132 chromosome 14 open reading frame 132
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CAB39 calcium binding protein 39
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CLIC5 chloride intracellular channel 5
COBL cordon-bleu WH2 repeat protein
CREBL2 cAMP responsive element binding protein-like 2
CRTAP cartilage associated protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTGF connective tissue growth factor
CTSH cathepsin H
DACH1 dachshund family transcription factor 1
DDR1 discoidin domain receptor tyrosine kinase 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DIAPH2 diaphanous-related formin 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNALI1 dynein, axonemal, light intermediate chain 1
DUSP4 dual specificity phosphatase 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFHC1 EF-hand domain (C-terminal) containing 1
EIF4B eukaryotic translation initiation factor 4B
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ETHE1 ethylmalonic encephalopathy 1
FAXDC2 fatty acid hydroxylase domain containing 2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOXO4 forkhead box O4
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPX3 glutathione peroxidase 3
GSDMB gasdermin B
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-E major histocompatibility complex, class I, E
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
IGBP1 immunoglobulin (CD79A) binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INSR insulin receptor
IRF6 interferon regulatory factor 6
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KIZ kizuna centrosomal protein
KRT19 keratin 19, type I
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LTA4H leukotriene A4 hydrolase
LXN latexin
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MLPH melanophilin
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MVP major vault protein
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NPDC1 neural proliferation, differentiation and control, 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSL1 obscurin-like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCCA propionyl CoA carboxylase, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PILRB paired immunoglobin-like type 2 receptor beta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRSS23 protease, serine, 23
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRO protein tyrosine phosphatase, receptor type, O
PXDN peroxidasin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RNASE4 ribonuclease, RNase A family, 4
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RNF103 ring finger protein 103
RPL15 ribosomal protein L15
RPL31 ribosomal protein L31
RPS11 ribosomal protein S11
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SNAP23 synaptosomal-associated protein, 23kDa
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SRGN serglycin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFF1 trefoil factor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX thymocyte selection-associated high mobility group box
TPP1 tripeptidyl peptidase I
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
USP6NL USP6 N-terminal like
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
WDR19 WD repeat domain 19
YPEL5 yippee-like 5 (Drosophila)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AK4 adenylate kinase 4
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BHLHE40 basic helix-loop-helix family, member e40
BLM Bloom syndrome, RecQ helicase-like
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRCA1 breast cancer 1, early onset
CA12 carbonic anhydrase XII
CACYBP calcyclin binding protein
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CLEC2B C-type lectin domain family 2, member B
CSRP2 cysteine and glycine-rich protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EREG epiregulin
EXO1 exonuclease 1
FANCI Fanconi anemia, complementation group I
FASTKD3 FAST kinase domains 3
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
GBP1 guanylate binding protein 1, interferon-inducible
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA14 heat shock 70kDa protein 14
IFI44L interferon-induced protein 44-like
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
INSIG1 insulin induced gene 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF23 kinesin family member 23
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LMO4 LIM domain only 4
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTERF3 mitochondrial transcription termination factor 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NQO1 NAD(P)H dehydrogenase, quinone 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PI3 peptidase inhibitor 3, skin-derived
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RAD54B RAD54 homolog B (S. cerevisiae)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RPA3 replication protein A3, 14kDa
RPP38 ribonuclease P/MRP 38kDa subunit
S100A2 S100 calcium binding protein A2
SCARB1 scavenger receptor class B, member 1
SESN1 sestrin 1
SFN stratifin
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SNX10 sorting nexin 10
SPC25 SPC25, NDC80 kinetochore complex component
SRP72 signal recognition particle 72kDa
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN2 transgelin 2
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TRIB3 tribbles pseudokinase 3
TRIP13 thyroid hormone receptor interactor 13
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
UPP1 uridine phosphorylase 1
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
ZWILCH zwilch kinetochore protein