BRD-A18328003_GDC-0980_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADGRG6 adhesion G protein-coupled receptor G6
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARG2 arginase 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
CCND2 cyclin D2
CCNG2 cyclin G2
CD24 CD24 molecule
CFD complement factor D (adipsin)
CHMP6 charged multivesicular body protein 6
CLDN3 claudin 3
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DMXL2 Dmx-like 2
EDNRB endothelin receptor type B
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM13A family with sequence similarity 13, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF13 fibroblast growth factor 13
FGFR3 fibroblast growth factor receptor 3
GALC galactosylceramidase
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
GREB1 growth regulation by estrogen in breast cancer 1
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1R insulin-like growth factor 1 receptor
IL13RA1 interleukin 13 receptor, alpha 1
ITGA7 integrin, alpha 7
JCHAIN joining chain of multimeric IgA and IgM
KDM3A lysine (K)-specific demethylase 3A
LGALS1 lectin, galactoside-binding, soluble, 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LXN latexin
MAOB monoamine oxidase B
MCAM melanoma cell adhesion molecule
MEIS2 Meis homeobox 2
MKRN1 makorin ring finger protein 1
MLANA melan-A
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK5 proprotein convertase subtilisin/kexin type 5
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLXNC1 plexin C1
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RND3 Rho family GTPase 3
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAD3 SMAD family member 3
SMYD3 SET and MYND domain containing 3
SOBP sine oculis binding protein homolog (Drosophila)
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STAR steroidogenic acute regulatory protein
STAT5B signal transducer and activator of transcription 5B
TBX3 T-box 3
TPM2 tropomyosin 2 (beta)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UGCG UDP-glucose ceramide glucosyltransferase
VAMP8 vesicle-associated membrane protein 8
VCAN versican
VCL vinculin
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALG8 ALG8, alpha-1,3-glucosyltransferase
BASP1 brain abundant, membrane attached signal protein 1
BTG3 BTG family, member 3
C14ORF132 chromosome 14 open reading frame 132
C3 complement component 3
CA2 carbonic anhydrase II
CCK cholecystokinin
CCL4 chemokine (C-C motif) ligand 4
CCND1 cyclin D1
CDC20 cell division cycle 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CP ceruloplasmin (ferroxidase)
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
FAM57A family with sequence similarity 57, member A
GLS glutaminase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFV H2A histone family, member V
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
LCN2 lipocalin 2
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MXRA5 matrix-remodelling associated 5
NIP7 NIP7, nucleolar pre-rRNA processing protein
ODC1 ornithine decarboxylase 1
OSBPL3 oxysterol binding protein-like 3
PER2 period circadian clock 2
PMM2 phosphomannomutase 2
PODXL podocalyxin-like
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PTPRK protein tyrosine phosphatase, receptor type, K
RGCC regulator of cell cycle
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOAT1 sterol O-acyltransferase 1
TPST2 tyrosylprotein sulfotransferase 2
TXNDC9 thioredoxin domain containing 9
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
ZBED2 zinc finger, BED-type containing 2