BRD-A18328003_GDC-0980_MCF7_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRF5 adhesion G protein-coupled receptor F5
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
BST2 bone marrow stromal cell antigen 2
BTN3A2 butyrophilin, subfamily 3, member A2
C10ORF10 chromosome 10 open reading frame 10
CA12 carbonic anhydrase XII
CD36 CD36 molecule (thrombospondin receptor)
COPS7A COP9 signalosome subunit 7A
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
E2F2 E2F transcription factor 2
EPS8 epidermal growth factor receptor pathway substrate 8
ERAP2 endoplasmic reticulum aminopeptidase 2
FADS1 fatty acid desaturase 1
FOXN3 forkhead box N3
GNS glucosamine (N-acetyl)-6-sulfatase
GREB1 growth regulation by estrogen in breast cancer 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
KIF14 kinesin family member 14
KRT18 keratin 18, type I
LEPROT leptin receptor overlapping transcript
MAP3K5 mitogen-activated protein kinase kinase kinase 5
METTL7A methyltransferase like 7A
MTUS1 microtubule associated tumor suppressor 1
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYLIP myosin regulatory light chain interacting protein
NEBL nebulette
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OSBPL8 oxysterol binding protein-like 8
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMA2 paraneoplastic Ma antigen 2
RBM47 RNA binding motif protein 47
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFRP4 secreted frizzled-related protein 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TFEC transcription factor EC
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1
VCAN versican
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
CES1 carboxylesterase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CTBP1 C-terminal binding protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
EGR1 early growth response 1
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EVL Enah/Vasp-like
IER5 immediate early response 5
LCN2 lipocalin 2
MMP9 matrix metallopeptidase 9
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
ORM1 orosomucoid 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PSENEN presenilin enhancer gamma secretase subunit
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STMN2 stathmin 2
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)