BRD-A18328003_GDC-0980_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AMDHD2 amidohydrolase domain containing 2
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDNRB endothelin receptor type B
ELOVL2 ELOVL fatty acid elongase 2
FABP7 fatty acid binding protein 7, brain
FOXO3 forkhead box O3
FXYD2 FXYD domain containing ion transport regulator 2
FZD6 frizzled class receptor 6
GDF15 growth differentiation factor 15
GNS glucosamine (N-acetyl)-6-sulfatase
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
IGL immunoglobulin lambda locus
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JCHAIN joining chain of multimeric IgA and IgM
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM3A lysine (K)-specific demethylase 3A
MAL mal, T-cell differentiation protein
MGP matrix Gla protein
MSMB microseminoprotein, beta-
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MXI1 MAX interactor 1, dimerization protein
NAP1L1 nucleosome assembly protein 1-like 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
PCM1 pericentriolar material 1
PDGFRL platelet-derived growth factor receptor-like
PLD1 phospholipase D1, phosphatidylcholine-specific
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SASH1 SAM and SH3 domain containing 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SMYD3 SET and MYND domain containing 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX10 sorting nexin 10
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TARBP1 TAR (HIV-1) RNA binding protein 1
TBX3 T-box 3
TM4SF1 transmembrane 4 L six family member 1
TUSC3 tumor suppressor candidate 3
UGCG UDP-glucose ceramide glucosyltransferase
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ANXA1 annexin A1
AREG amphiregulin
AUTS2 autism susceptibility candidate 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKB creatine kinase, brain
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DBN1 drebrin 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EIF1B eukaryotic translation initiation factor 1B
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FAM129A family with sequence similarity 129, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FSCN1 fascin actin-bundling protein 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX1 glutathione peroxidase 1
HSPA1A heat shock 70kDa protein 1A
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
JMJD6 jumonji domain containing 6
LPL lipoprotein lipase
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
ORM1 orosomucoid 1
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA2 pleckstrin homology-like domain, family A, member 2
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SIRT3 sirtuin 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)