BRD-A18328003_GDC-0980_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2 B-cell CLL/lymphoma 2
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG1 cyclin G1
CCNG2 cyclin G2
CEP68 centrosomal protein 68kDa
COLEC12 collectin sub-family member 12
CREBL2 cAMP responsive element binding protein-like 2
CTGF connective tissue growth factor
DALRD3 DALR anticodon binding domain containing 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FAM63A family with sequence similarity 63, member A
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GAS6 growth arrest-specific 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GMPR guanosine monophosphate reductase
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KDM3A lysine (K)-specific demethylase 3A
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
METTL7A methyltransferase like 7A
MGLL monoglyceride lipase
MPPED2 metallophosphoesterase domain containing 2
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
NPDC1 neural proliferation, differentiation and control, 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPHN1 oligophrenin 1
PAWR PRKC, apoptosis, WT1, regulator
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
QARS glutaminyl-tRNA synthetase
RB1CC1 RB1-inducible coiled-coil 1
RBP1 retinol binding protein 1, cellular
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC35E2B solute carrier family 35, member E2B
SPATA20 spermatogenesis associated 20
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
UBXN1 UBX domain protein 1
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WT1 Wilms tumor 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ATAD2 ATPase family, AAA domain containing 2
C20ORF24 chromosome 20 open reading frame 24
CCNA2 cyclin A2
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CLU clusterin
CMC2 C-x(9)-C motif containing 2
CSTA cystatin A (stefin A)
CYBA cytochrome b-245, alpha polypeptide
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
G6PD glucose-6-phosphate dehydrogenase
GALE UDP-galactose-4-epimerase
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
H2AFX H2A histone family, member X
HOPX HOP homeobox
HSPA14 heat shock 70kDa protein 14
IDI1 isopentenyl-diphosphate delta isomerase 1
JMJD6 jumonji domain containing 6
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
NME1 NME/NM23 nucleoside diphosphate kinase 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA3 replication protein A3, 14kDa
RRBP1 ribosome binding protein 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCEL sciellin
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN2 transgelin 2
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TLR4 toll-like receptor 4
TMPO thymopoietin
TNC tenascin C
TUBA4A tubulin, alpha 4a
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein