BRD-A18328003_GDC-0980_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRG6 adhesion G protein-coupled receptor G6
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG1 cyclin G1
CCNG2 cyclin G2
CD200 CD200 molecule
CD44 CD44 molecule (Indian blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLEC2B C-type lectin domain family 2, member B
COLEC12 collectin sub-family member 12
CREBL2 cAMP responsive element binding protein-like 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
EFNA1 ephrin-A1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FXYD3 FXYD domain containing ion transport regulator 3
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSN gelsolin
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
KDM3A lysine (K)-specific demethylase 3A
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
MAOA monoamine oxidase A
MGLL monoglyceride lipase
MT1X metallothionein 1X
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
NAV2 neuron navigator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRCAM neuronal cell adhesion molecule
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae)
NT5E 5'-nucleotidase, ecto (CD73)
PERP PERP, TP53 apoptosis effector
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
QPCT glutaminyl-peptide cyclotransferase
RALGDS ral guanine nucleotide dissociation stimulator
RNASET2 ribonuclease T2
RPL22 ribosomal protein L22
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SOCS2 suppressor of cytokine signaling 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRPX sushi-repeat containing protein, X-linked
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TXNIP thioredoxin interacting protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ATAD2 ATPase family, AAA domain containing 2
C20ORF24 chromosome 20 open reading frame 24
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
DHCR24 24-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EREG epiregulin
FEN1 flap structure-specific endonuclease 1
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
MAK16 MAK16 homolog (S. cerevisiae)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
RANBP1 RAN binding protein 1
RCAN2 regulator of calcineurin 2
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDF2L1 stromal cell-derived factor 2-like 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMCO4 single-pass membrane protein with coiled-coil domains 4
STRA13 stimulated by retinoic acid 13
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFRC transferrin receptor
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TLR4 toll-like receptor 4
TRAPPC3 trafficking protein particle complex 3
TUBA4A tubulin, alpha 4a
TUBG1 tubulin, gamma 1
VRK1 vaccinia related kinase 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein