BRD-A18328003_GDC-0980_MCF7_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF7_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG1 cyclin G1
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP68 centrosomal protein 68kDa
CREBL2 cAMP responsive element binding protein-like 2
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
HIST1H2AC histone cluster 1, H2ac
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
KIZ kizuna centrosomal protein
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
MAST4 microtubule associated serine/threonine kinase family member 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
PCP4 Purkinje cell protein 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RPL15 ribosomal protein L15
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SLC35E2B solute carrier family 35, member E2B
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS2 suppressor of cytokine signaling 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZBTB38 zinc finger and BTB domain containing 38
ZNF277 zinc finger protein 277
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ATAD2 ATPase family, AAA domain containing 2
BTG3 BTG family, member 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CD320 CD320 molecule
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CFH complement factor H
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CSTA cystatin A (stefin A)
DCXR dicarbonyl/L-xylulose reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ERGIC2 ERGIC and golgi 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GOLT1B golgi transport 1B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
LRRC59 leucine rich repeat containing 59
MAK16 MAK16 homolog (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MRPL12 mitochondrial ribosomal protein L12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPR3 natriuretic peptide receptor 3
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PEA15 phosphoprotein enriched in astrocytes 15
PNP purine nucleoside phosphorylase
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RCAN2 regulator of calcineurin 2
RRM2 ribonucleotide reductase M2
SFN stratifin
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TDO2 tryptophan 2,3-dioxygenase
TFRC transferrin receptor
TLR4 toll-like receptor 4
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1