BRD-A18328003_GDC-0980_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CAV2 caveolin 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCR4 chemokine (C-X-C motif) receptor 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFNA1 ephrin-A1
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FOXN3 forkhead box N3
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
MAOB monoamine oxidase B
MME membrane metallo-endopeptidase
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTK2 protein tyrosine kinase 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBPMS RNA binding protein with multiple splicing
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TJP2 tight junction protein 2
TMPRSS3 transmembrane protease, serine 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
VAV3 vav 3 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AMD1 adenosylmethionine decarboxylase 1
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IL1B interleukin 1, beta
JMJD6 jumonji domain containing 6
KCTD5 potassium channel tetramerization domain containing 5
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LEF1 lymphoid enhancer-binding factor 1
LPXN leupaxin
LRP4 low density lipoprotein receptor-related protein 4
MAT2A methionine adenosyltransferase II, alpha
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIP7 NIP7, nucleolar pre-rRNA processing protein
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLAUR plasminogen activator, urokinase receptor
PODXL podocalyxin-like
POLR1C polymerase (RNA) I polypeptide C, 30kDa
RNPS1 RNA binding protein S1, serine-rich domain
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB1 SATB homeobox 1
SATB2 SATB homeobox 2
SFN stratifin
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
SRSF1 serine/arginine-rich splicing factor 1
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TOR1A torsin family 1, member A (torsin A)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing