BRD-A18328003_GDC-0980_MCF10A_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF10A_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG1 adhesion G protein-coupled receptor G1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
ATM ATM serine/threonine kinase
ATP9A ATPase, class II, type 9A
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL2 chemokine (C-C motif) ligand 2
CCNG2 cyclin G2
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CXCR4 chemokine (C-X-C motif) receptor 4
DEPTOR DEP domain containing MTOR-interacting protein
DPYSL2 dihydropyrimidinase-like 2
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPN2 epsin 2
EPS8 epidermal growth factor receptor pathway substrate 8
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOXN3 forkhead box N3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAS GNAS complex locus
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
KLHL24 kelch-like family member 24
LXN latexin
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NMU neuromedin U
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PER1 period circadian clock 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPARG peroxisome proliferator-activated receptor gamma
PPL periplakin
PTGIS prostaglandin I2 (prostacyclin) synthase
PTK2 protein tyrosine kinase 2
RB1CC1 RB1-inducible coiled-coil 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SH3BGRL SH3 domain binding glutamate-rich protein like
SKAP2 src kinase associated phosphoprotein 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
TACC2 transforming, acidic coiled-coil containing protein 2
TBC1D15 TBC1 domain family, member 15
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
YBX3 Y box binding protein 3
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADM adrenomedullin
APOA2 apolipoprotein A-II
BHLHE40 basic helix-loop-helix family, member e40
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL9 chemokine (C-X-C motif) ligand 9
DACH1 dachshund family transcription factor 1
EGR2 early growth response 2
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
HBEGF heparin-binding EGF-like growth factor
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MMP9 matrix metallopeptidase 9
NGRN neugrin, neurite outgrowth associated
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PNO1 partner of NOB1 homolog (S. cerevisiae)
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTHLH parathyroid hormone-like hormone
RGS5 regulator of G-protein signaling 5
RPIA ribose 5-phosphate isomerase A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLPI secretory leukocyte peptidase inhibitor
SNX11 sorting nexin 11
SRSF7 serine/arginine-rich splicing factor 7
TAGLN transgelin
TF transferrin
TFF1 trefoil factor 1
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
VEGFA vascular endothelial growth factor A
ZBED2 zinc finger, BED-type containing 2
ZDHHC6 zinc finger, DHHC-type containing 6