BRD-A18328003_GDC-0980_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA1 annexin A1
ANXA4 annexin A4
APOE apolipoprotein E
ARG2 arginase 2
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL12 chemokine (C-X-C motif) ligand 12
E2F2 E2F transcription factor 2
ESR1 estrogen receptor 1
FAXDC2 fatty acid hydroxylase domain containing 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GREB1 growth regulation by estrogen in breast cancer 1
HBP1 HMG-box transcription factor 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
JCHAIN joining chain of multimeric IgA and IgM
LPAR6 lysophosphatidic acid receptor 6
METTL7A methyltransferase like 7A
MMP7 matrix metallopeptidase 7
OPN3 opsin 3
ORAI3 ORAI calcium release-activated calcium modulator 3
PNKP polynucleotide kinase 3'-phosphatase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTK2 protein tyrosine kinase 2
RAB13 RAB13, member RAS oncogene family
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
STOM stomatin
SYNE2 spectrin repeat containing, nuclear envelope 2
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAV3 vav 3 guanine nucleotide exchange factor
XIST X inactive specific transcript (non-protein coding)
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APP amyloid beta (A4) precursor protein
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AUTS2 autism susceptibility candidate 2
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL5A1 collagen, type V, alpha 1
CREB1 cAMP responsive element binding protein 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DKC1 dyskeratosis congenita 1, dyskerin
EIF4A1 eukaryotic translation initiation factor 4A1
EREG epiregulin
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSL1 FOS-like antigen 1
HIST1H4C histone cluster 1, H4c
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IFITM2 interferon induced transmembrane protein 2
LRRC8D leucine rich repeat containing 8 family, member D
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOP2 NOP2 nucleolar protein
NRN1 neuritin 1
OXA1L oxidase (cytochrome c) assembly 1-like
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PODXL podocalyxin-like
RBM34 RNA binding motif protein 34
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SCG2 secretogranin II
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SNX7 sorting nexin 7
SPP1 secreted phosphoprotein 1
ZYX zyxin