BRD-A18328003_GDC-0980_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

367 genes differentially expressed following the BRD-A18328003_GDC-0980_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP9A ATPase, class II, type 9A
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BCAS1 breast carcinoma amplified sequence 1
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C19ORF66 chromosome 19 open reading frame 66
C1RL complement component 1, r subcomponent-like
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CAV2 caveolin 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP57 centrosomal protein 57kDa
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLIC5 chloride intracellular channel 5
CP ceruloplasmin (ferroxidase)
CPQ carboxypeptidase Q
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSA cathepsin A
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH2 dimethylarginine dimethylaminohydrolase 2
DYNLT3 dynein, light chain, Tctex-type 3
EFNA1 ephrin-A1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM13B family with sequence similarity 13, member B
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GATAD1 GATA zinc finger domain containing 1
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPR137B G protein-coupled receptor 137B
GRAMD3 GRAM domain containing 3
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KIAA0430 KIAA0430
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K5 mitogen-activated protein kinase kinase 5
MSLN mesothelin
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
MYO1D myosin ID
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PINK1 PTEN induced putative kinase 1
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLSCR4 phospholipid scramblase 4
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
QARS glutaminyl-tRNA synthetase
RAB13 RAB13, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RHOQ ras homolog family member Q
RPS11 ribosomal protein S11
RRAGC Ras-related GTP binding C
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SFXN3 sideroflexin 3
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SP110 SP110 nuclear body protein
SPINK1 serine peptidase inhibitor, Kazal type 1
STX7 syntaxin 7
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYF2 SYF2 pre-mRNA-splicing factor
TMC5 transmembrane channel-like 5
TMEM30B transmembrane protein 30B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRAF5 TNF receptor-associated factor 5
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TRIM8 tripartite motif containing 8
TSPAN31 tetraspanin 31
TTC3 tetratricopeptide repeat domain 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZC2HC1A zinc finger, C2HC-type containing 1A
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP3 aquaporin 3 (Gill blood group)
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
AURKA aurora kinase A
AURKB aurora kinase B
BANF1 barrier to autointegration factor 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
C20ORF24 chromosome 20 open reading frame 24
CCNA2 cyclin A2
CCNF cyclin F
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FST follistatin
GAL galanin/GMAP prepropeptide
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPM heterogeneous nuclear ribonucleoprotein M
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFRD2 interferon-related developmental regulator 2
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
KIAA0020 KIAA0020
KIAA0101 KIAA0101
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP155 nucleoporin 155kDa
NUP205 nucleoporin 205kDa
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB1 scavenger receptor class B, member 1
SDF2L1 stromal cell-derived factor 2-like 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TFRC transferrin receptor
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein