BRD-A18328003_GDC-0980_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-A18328003_GDC-0980_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP9A ATPase, class II, type 9A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG1 cyclin G1
CCNG2 cyclin G2
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFI complement factor I
CHGB chromogranin B
CLIC5 chloride intracellular channel 5
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CTSA cathepsin A
DACH1 dachshund family transcription factor 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EFNA1 ephrin-A1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAXDC2 fatty acid hydroxylase domain containing 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FSTL1 follistatin-like 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GOLGB1 golgin B1
GPR137B G protein-coupled receptor 137B
GRAMD1C GRAM domain containing 1C
GSDMB gasdermin B
GSTT1 glutathione S-transferase theta 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEPH hephaestin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICA1 islet cell autoantigen 1, 69kDa
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRF7 interferon regulatory factor 7
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
KRT23 keratin 23, type I
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MTMR11 myotubularin related protein 11
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NMRK1 nicotinamide riboside kinase 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLA2G16 phospholipase A2, group XVI
PLCB4 phospholipase C, beta 4
PLSCR4 phospholipid scramblase 4
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
QPCT glutaminyl-peptide cyclotransferase
RAB40B RAB40B, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC35E2B solute carrier family 35, member E2B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STXBP1 syntaxin binding protein 1
SYF2 SYF2 pre-mRNA-splicing factor
TANK TRAF family member-associated NFKB activator
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOX thymocyte selection-associated high mobility group box
TPP1 tripeptidyl peptidase I
TRAM1 translocation associated membrane protein 1
TRIB1 tribbles pseudokinase 1
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
USH1C Usher syndrome 1C (autosomal recessive, severe)
WDR45 WD repeat domain 45
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator
YPEL5 yippee-like 5 (Drosophila)
ZBTB10 zinc finger and BTB domain containing 10
ZFPM2 zinc finger protein, FOG family member 2
ZNF277 zinc finger protein 277
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CIT citron rho-interacting serine/threonine kinase
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A6 collagen, type IV, alpha 6
COTL1 coactosin-like F-actin binding protein 1
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP3 epithelial membrane protein 3
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
IGKC immunoglobulin kappa constant
KRT15 keratin 15, type I
LBR lamin B receptor
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSPH phosphoserine phosphatase
PTGES prostaglandin E synthase
PTTG1 pituitary tumor-transforming 1
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SPAG5 sperm associated antigen 5
SRM spermidine synthase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein