BRD-A18328003_GDC-0980_HS578T_3_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-A18328003_GDC-0980_HS578T_3_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABHD4 abhydrolase domain containing 4
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASPN asporin
BGN biglycan
BTG2 BTG family, member 2
CCNG1 cyclin G1
CCNG2 cyclin G2
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL14A1 collagen, type XIV, alpha 1
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
DCN decorin
DUSP6 dual specificity phosphatase 6
F2R coagulation factor II (thrombin) receptor
FHL1 four and a half LIM domains 1
FST follistatin
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GPM6B glycoprotein M6B
GSPT2 G1 to S phase transition 2
HECA headcase homolog (Drosophila)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2A integral membrane protein 2A
LPAR6 lysophosphatidic acid receptor 6
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MYH11 myosin, heavy chain 11, smooth muscle
NFIB nuclear factor I/B
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS5 regulator of G-protein signaling 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRPX sushi-repeat containing protein, X-linked
THBS2 thrombospondin 2
THBS4 thrombospondin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VLDLR very low density lipoprotein receptor
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
BST2 bone marrow stromal cell antigen 2
CDC25A cell division cycle 25A
CLIC5 chloride intracellular channel 5
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
HSPA1A heat shock 70kDa protein 1A
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
MUC16 mucin 16, cell surface associated
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SRSF7 serine/arginine-rich splicing factor 7
TNFRSF21 tumor necrosis factor receptor superfamily, member 21