BRD-A18328003_GDC-0980_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-A18328003_GDC-0980_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADRB2 adrenoceptor beta 2, surface
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ARG1 arginase 1
ASPN asporin
AXIN1 axin 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CIRBP cold inducible RNA binding protein
CLEC3B C-type lectin domain family 3, member B
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
CYBRD1 cytochrome b reductase 1
DARS aspartyl-tRNA synthetase
DPP4 dipeptidyl-peptidase 4
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM8A1 family with sequence similarity 8, member A1
FNBP1 formin binding protein 1
FOXO4 forkhead box O4
HAL histidine ammonia-lyase
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
IGFBP1 insulin-like growth factor binding protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JADE2 jade family PHD finger 2
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
LINC00341 long intergenic non-protein coding RNA 341
LPAR1 lysophosphatidic acid receptor 1
LPIN1 lipin 1
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MAST4 microtubule associated serine/threonine kinase family member 4
MXRA7 matrix-remodelling associated 7
MYOF myoferlin
NBPF10 neuroblastoma breakpoint family, member 10
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2NL notch 2 N-terminal like
NPY1R neuropeptide Y receptor Y1
NT5E 5'-nucleotidase, ecto (CD73)
OPTN optineurin
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PHIP pleckstrin homology domain interacting protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSD3 pleckstrin and Sec7 domain containing 3
RHOF ras homolog family member F (in filopodia)
RNF144A ring finger protein 144A
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SH3YL1 SH3 and SYLF domain containing 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SSFA2 sperm specific antigen 2
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TRAK2 trafficking protein, kinesin binding 2
TSC22D1 TSC22 domain family, member 1
TYRP1 tyrosinase-related protein 1
VNN1 vanin 1
ZBTB16 zinc finger and BTB domain containing 16
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCHE butyrylcholinesterase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAPZB capping protein (actin filament) muscle Z-line, beta
CD38 CD38 molecule
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFI complement factor I
CNN3 calponin 3, acidic
COTL1 coactosin-like F-actin binding protein 1
CTPS1 CTP synthase 1
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGFL6 EGF-like-domain, multiple 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
FEN1 flap structure-specific endonuclease 1
FILIP1L filamin A interacting protein 1-like
FKBP14 FK506 binding protein 14, 22 kDa
FOLR1 folate receptor 1 (adult)
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSTT1 glutathione S-transferase theta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICMT isoprenylcysteine carboxyl methyltransferase
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
LIMCH1 LIM and calponin homology domains 1
MARS methionyl-tRNA synthetase
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRMT1 protein arginine methyltransferase 1
PSENEN presenilin enhancer gamma secretase subunit
PYCR1 pyrroline-5-carboxylate reductase 1
RFC2 replication factor C (activator 1) 2, 40kDa
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPA2 surfactant protein A2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SQLE squalene epoxidase
STC2 stanniocalcin 2
TAGLN transgelin
TARS threonyl-tRNA synthetase
TDO2 tryptophan 2,3-dioxygenase
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TK1 thymidine kinase 1, soluble
TP53 tumor protein p53
TRIP13 thyroid hormone receptor interactor 13
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase