BRD-A18328003_GDC-0980_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

232 genes differentially expressed following the BRD-A18328003_GDC-0980_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADD3 adducin 3 (gamma)
ANGPTL2 angiopoietin-like 2
ANKRD36B ankyrin repeat domain 36B
ARHGAP12 Rho GTPase activating protein 12
ASPN asporin
ATP9A ATPase, class II, type 9A
BDH2 3-hydroxybutyrate dehydrogenase, type 2
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CDK19 cyclin-dependent kinase 19
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CIZ1 CDKN1A interacting zinc finger protein 1
CLEC2B C-type lectin domain family 2, member B
COL18A1 collagen, type XVIII, alpha 1
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CTSK cathepsin K
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBRD1 cytochrome b reductase 1
DARS aspartyl-tRNA synthetase
DCLK1 doublecortin-like kinase 1
DCN decorin
DEFB1 defensin, beta 1
DLG5 discs, large homolog 5 (Drosophila)
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF4B eukaryotic translation initiation factor 4B
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD2 FXYD domain containing ion transport regulator 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX4 glutathione peroxidase 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYPC glycophorin C (Gerbich blood group)
HDAC6 histone deacetylase 6
HIST3H2A histone cluster 3, H2a
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS1 insulin receptor substrate 1
ITM2A integral membrane protein 2A
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLHL21 kelch-like family member 21
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LHX2 LIM homeobox 2
LINC00341 long intergenic non-protein coding RNA 341
MYO6 myosin VI
N4BP2L1 NEDD4 binding protein 2-like 1
NCALD neurocalcin delta
NISCH nischarin
NONO non-POU domain containing, octamer-binding
NOTCH2NL notch 2 N-terminal like
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG3 paternally expressed 3
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHYH phytanoyl-CoA 2-hydroxylase
PRKCSH protein kinase C substrate 80K-H
PROS1 protein S (alpha)
QARS glutaminyl-tRNA synthetase
RNASET2 ribonuclease T2
RPL36 ribosomal protein L36
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPON2 spondin 2, extracellular matrix protein
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
SSPN sarcospan
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TANK TRAF family member-associated NFKB activator
THYN1 thymocyte nuclear protein 1
TRIB2 tribbles pseudokinase 2
TRPS1 trichorhinophalangeal syndrome I
TTC3 tetratricopeptide repeat domain 3
VAT1 vesicle amine transport 1
VCAN versican
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292
ZNF451 zinc finger protein 451
ZNF83 zinc finger protein 83
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACTC1 actin, alpha, cardiac muscle 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QBP complement component 1, q subcomponent binding protein
C8ORF4 chromosome 8 open reading frame 4
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKAP4 cytoskeleton-associated protein 4
COL5A1 collagen, type V, alpha 1
CTPS1 CTP synthase 1
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EGFL6 EGF-like-domain, multiple 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
FEN1 flap structure-specific endonuclease 1
FILIP1L filamin A interacting protein 1-like
FOLR1 folate receptor 1 (adult)
GALE UDP-galactose-4-epimerase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
GPX2 glutathione peroxidase 2
HSPB8 heat shock 22kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
KRT18 keratin 18, type I
KRT7 keratin 7, type II
L1CAM L1 cell adhesion molecule
LIMCH1 LIM and calponin homology domains 1
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
MARS methionyl-tRNA synthetase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDNF neuron-derived neurotrophic factor
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PDIA3 protein disulfide isomerase family A, member 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHB prohibitin
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCH protein kinase C, eta
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RANBP1 RAN binding protein 1
RGS1 regulator of G-protein signaling 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35B1 solute carrier family 35, member B1
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTSSA serine palmitoyltransferase, small subunit A
STRA13 stimulated by retinoic acid 13
TARP TCR gamma alternate reading frame protein
TARS threonyl-tRNA synthetase
TGFBI transforming growth factor, beta-induced, 68kDa
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMELESS timeless circadian clock
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMEM176B transmembrane protein 176B
TNNC1 troponin C type 1 (slow)
TRIP13 thyroid hormone receptor interactor 13
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon