BRD-A18328003_GDC-0980_HS578T_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-A18328003_GDC-0980_HS578T_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ADRB2 adrenoceptor beta 2, surface
ANGPT1 angiopoietin 1
ANXA1 annexin A1
AOX1 aldehyde oxidase 1
APOE apolipoprotein E
ARID5B AT rich interactive domain 5B (MRF1-like)
ASPN asporin
ATP9A ATPase, class II, type 9A
BEX1 brain expressed, X-linked 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CCND1 cyclin D1
CCNG2 cyclin G2
CD22 CD22 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CPD carboxypeptidase D
CPT1A carnitine palmitoyltransferase 1A (liver)
CTGF connective tissue growth factor
CYFIP2 cytoplasmic FMR1 interacting protein 2
DARS aspartyl-tRNA synthetase
DCN decorin
DEFB1 defensin, beta 1
DLG5 discs, large homolog 5 (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPP4 dipeptidyl-peptidase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM8A1 family with sequence similarity 8, member A1
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HOPX HOP homeobox
HP haptoglobin
IDS iduronate 2-sulfatase
IRS1 insulin receptor substrate 1
LPAR1 lysophosphatidic acid receptor 1
MGP matrix Gla protein
MYO6 myosin VI
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
REEP5 receptor accessory protein 5
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35F2 solute carrier family 35, member F2
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
SPRED2 sprouty-related, EVH1 domain containing 2
STK39 serine threonine kinase 39
SYNE2 spectrin repeat containing, nuclear envelope 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB2 tribbles pseudokinase 2
VCAN versican
VNN1 vanin 1

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ACTA1 actin, alpha 1, skeletal muscle
ASS1 argininosuccinate synthase 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CKB creatine kinase, brain
CKLF chemokine-like factor
CKM creatine kinase, muscle
CREB1 cAMP responsive element binding protein 1
CTPS1 CTP synthase 1
DDIT4 DNA-damage-inducible transcript 4
DES desmin
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAR2 fatty acyl CoA reductase 2
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
NEB nebulin
NET1 neuroepithelial cell transforming 1
NLRP2 NLR family, pyrin domain containing 2
NRG1 neuregulin 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PHB prohibitin
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PRPS1 phosphoribosyl pyrophosphate synthetase 1
RAD23B RAD23 homolog B (S. cerevisiae)
RCAN1 regulator of calcineurin 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TK1 thymidine kinase 1, soluble
TMED2 transmembrane emp24 domain trafficking protein 2
TMPO thymopoietin
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TTN titin
ZWINT ZW10 interacting kinetochore protein