BRD-A18328003_GDC-0980_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-A18328003_GDC-0980_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASCL1 achaete-scute family bHLH transcription factor 1
BBS1 Bardet-Biedl syndrome 1
BEX1 brain expressed, X-linked 1
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CCNG2 cyclin G2
CCP110 centriolar coiled coil protein 110kDa
CPT1A carnitine palmitoyltransferase 1A (liver)
CRIP1 cysteine-rich protein 1 (intestinal)
CSNK2A2 casein kinase 2, alpha prime polypeptide
CUTA cutA divalent cation tolerance homolog (E. coli)
DALRD3 DALR anticodon binding domain containing 3
DEPTOR DEP domain containing MTOR-interacting protein
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFNA1 ephrin-A1
EIF4B eukaryotic translation initiation factor 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM134A family with sequence similarity 134, member A
FAM134B family with sequence similarity 134, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GABARAPL1 GABA(A) receptor-associated protein like 1
GAS6 growth arrest-specific 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRN granulin
GSN gelsolin
HDAC5 histone deacetylase 5
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSR insulin receptor
JUP junction plakoglobin
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIZ kizuna centrosomal protein
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMB2 laminin, beta 2 (laminin S)
LAMP5 lysosomal-associated membrane protein family, member 5
LETMD1 LETM1 domain containing 1
LGALS8 lectin, galactoside-binding, soluble, 8
LOC399491
LZTFL1 leucine zipper transcription factor-like 1
MAGEA3 melanoma antigen family A3
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
METTL7A methyltransferase like 7A
MLPH melanophilin
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL1A oxysterol binding protein-like 1A
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PSAP prosaposin
QARS glutaminyl-tRNA synthetase
RAB13 RAB13, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RBPMS RNA binding protein with multiple splicing
RIOK3 RIO kinase 3
RPL31 ribosomal protein L31
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SGSM2 small G protein signaling modulator 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TCTA T-cell leukemia translocation altered
TKT transketolase
TMEM135 transmembrane protein 135
TMEM159 transmembrane protein 159
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
VAT1 vesicle amine transport 1
VCAN versican
VDAC1 voltage-dependent anion channel 1
WDTC1 WD and tetratricopeptide repeats 1
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BOP1 block of proliferation 1
CALML4 calmodulin-like 4
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEP55 centrosomal protein 55kDa
CNN3 calponin 3, acidic
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSRP2 cysteine and glycine-rich protein 2
CTPS1 CTP synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHFR dihydrofolate reductase
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFNB2 ephrin-B2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
LTF lactotransferrin
LUM lumican
LYZ lysozyme
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MMP12 matrix metallopeptidase 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEK7 NIMA-related kinase 7
NOLC1 nucleolar and coiled-body phosphoprotein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS2 protease, serine, 2 (trypsin 2)
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
REG3A regenerating islet-derived 3 alpha
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
S100A8 S100 calcium binding protein A8
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR3 small proline-rich protein 3
SRGN serglycin
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK17A serine/threonine kinase 17a
TFRC transferrin receptor
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TSC22D2 TSC22 domain family, member 2
TUBG1 tubulin, gamma 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein