BRD-A18328003_GDC-0980_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-A18328003_GDC-0980_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAT1 adenosine deaminase, tRNA-specific 1
ANXA3 annexin A3
ARG1 arginase 1
ASPN asporin
ATP9A ATPase, class II, type 9A
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CD44 CD44 molecule (Indian blood group)
CD99 CD99 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSK cathepsin K
CYBRD1 cytochrome b reductase 1
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
FAP fibroblast activation protein, alpha
GALC galactosylceramidase
GBP2 guanylate binding protein 2, interferon-inducible
GCC2 GRIP and coiled-coil domain containing 2
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPR161 G protein-coupled receptor 161
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPX4 glutathione peroxidase 4
HES1 hes family bHLH transcription factor 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI16 interferon, gamma-inducible protein 16
IQGAP1 IQ motif containing GTPase activating protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KLHDC2 kelch domain containing 2
LTA4H leukotriene A4 hydrolase
MACF1 microtubule-actin crosslinking factor 1
MMP11 matrix metallopeptidase 11
MPDZ multiple PDZ domain protein
MYLK myosin light chain kinase
NONO non-POU domain containing, octamer-binding
NPDC1 neural proliferation, differentiation and control, 1
NT5E 5'-nucleotidase, ecto (CD73)
PBX1 pre-B-cell leukemia homeobox 1
PLIN1 perilipin 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SOX4 SRY (sex determining region Y)-box 4
SSFA2 sperm specific antigen 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TANK TRAF family member-associated NFKB activator
TGIF1 TGFB-induced factor homeobox 1
TMEM204 transmembrane protein 204
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VAT1 vesicle amine transport 1
WDR19 WD repeat domain 19
ZBTB16 zinc finger and BTB domain containing 16
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADA adenosine deaminase
ADGRG1 adhesion G protein-coupled receptor G1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANXA6 annexin A6
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1ORF116 chromosome 1 open reading frame 116
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CDC42 cell division cycle 42
CLU clusterin
CTSC cathepsin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAF2 ELL associated factor 2
EGF epidermal growth factor
EIF4E eukaryotic translation initiation factor 4E
ENO1 enolase 1, (alpha)
FAM46C family with sequence similarity 46, member C
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LDLR low density lipoprotein receptor
LRRC59 leucine rich repeat containing 59
MAL mal, T-cell differentiation protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMO1 methylsterol monooxygenase 1
NELL1 NEL-like 1 (chicken)
OAT ornithine aminotransferase
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDIA3 protein disulfide isomerase family A, member 3
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
PNP purine nucleoside phosphorylase
PON2 paraoxonase 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
PYCR1 pyrroline-5-carboxylate reductase 1
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOB ras homolog family member B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SDC2 syndecan 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
SRPRB signal recognition particle receptor, B subunit
TBC1D4 TBC1 domain family, member 4
TFRC transferrin receptor
TMED9 transmembrane emp24 protein transport domain containing 9
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX3 TOX high mobility group box family member 3
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon