BRD-A18328003_GDC-0980_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-A18328003_GDC-0980_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANKRD36B ankyrin repeat domain 36B
ATG2A autophagy related 2A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
C1RL complement component 1, r subcomponent-like
CCDC28A coiled-coil domain containing 28A
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CTSA cathepsin A
CTSB cathepsin B
CTSS cathepsin S
DHRS3 dehydrogenase/reductase (SDR family) member 3
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
EXPH5 exophilin 5
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FRY furry homolog (Drosophila)
FST follistatin
FUCA1 fucosidase, alpha-L- 1, tissue
GAA glucosidase, alpha; acid
GLUL glutamate-ammonia ligase
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H3H histone cluster 1, H3h
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
LTBP1 latent transforming growth factor beta binding protein 1
MAN2B1 mannosidase, alpha, class 2B, member 1
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
NBR1 neighbor of BRCA1 gene 1
NPDC1 neural proliferation, differentiation and control, 1
PCGF2 polycomb group ring finger 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SGK1 serum/glucocorticoid regulated kinase 1
SOX4 SRY (sex determining region Y)-box 4
TCF4 transcription factor 4
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TMSB15A thymosin beta 15a
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZNF24 zinc finger protein 24

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA3 annexin A3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CDC6 cell division cycle 6
CKS1B CDC28 protein kinase regulatory subunit 1B
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYB561 cytochrome b561
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1L dynamin 1-like
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FAM57A family with sequence similarity 57, member A
FGFR2 fibroblast growth factor receptor 2
FSCN1 fascin actin-bundling protein 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLS glutaminase
GPI glucose-6-phosphate isomerase
GSTM3 glutathione S-transferase mu 3 (brain)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IARS isoleucyl-tRNA synthetase
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LPL lipoprotein lipase
MCM10 minichromosome maintenance complex component 10
MFAP5 microfibrillar associated protein 5
MRPL12 mitochondrial ribosomal protein L12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPR3 natriuretic peptide receptor 3
NRIP1 nuclear receptor interacting protein 1
NUP205 nucleoporin 205kDa
PCNA proliferating cell nuclear antigen
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PRDX4 peroxiredoxin 4
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAD51C RAD51 paralog C
RAN RAN, member RAS oncogene family
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLPI secretory leukocyte peptidase inhibitor
STAT1 signal transducer and activator of transcription 1, 91kDa
TES testin LIM domain protein
TFRC transferrin receptor
TMEM45A transmembrane protein 45A
TPM1 tropomyosin 1 (alpha)
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ZWINT ZW10 interacting kinetochore protein