BRD-A18328003_GDC-0980_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-A18328003_GDC-0980_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ANKRD10 ankyrin repeat domain 10
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AUH AU RNA binding protein/enoyl-CoA hydratase
BACE2 beta-site APP-cleaving enzyme 2
BRD8 bromodomain containing 8
CALCOCO1 calcium binding and coiled-coil domain 1
CAMLG calcium modulating ligand
CAST calpastatin
CBX7 chromobox homolog 7
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CREBL2 cAMP responsive element binding protein-like 2
CTSA cathepsin A
CTSS cathepsin S
CYTH1 cytohesin 1
DUSP22 dual specificity phosphatase 22
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM102A family with sequence similarity 102, member A
FOXN3 forkhead box N3
FZD6 frizzled class receptor 6
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCC2 GRIP and coiled-coil domain containing 2
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GRN granulin
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
KDM3A lysine (K)-specific demethylase 3A
KIF13B kinesin family member 13B
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
METTL7A methyltransferase like 7A
MLANA melan-A
MXI1 MAX interactor 1, dimerization protein
MYLIP myosin regulatory light chain interacting protein
N4BP2L1 NEDD4 binding protein 2-like 1
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPDC1 neural proliferation, differentiation and control, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OXA1L oxidase (cytochrome c) assembly 1-like
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PHF1 PHD finger protein 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PMEL premelanosome protein
RALGDS ral guanine nucleotide dissociation stimulator
RB1CC1 RB1-inducible coiled-coil 1
RBP1 retinol binding protein 1, cellular
RTN2 reticulon 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
STON1 stonin 1
STXBP2 syntaxin binding protein 2
SYF2 SYF2 pre-mRNA-splicing factor
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
UBE2B ubiquitin-conjugating enzyme E2B
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANXA3 annexin A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA2 carbonic anhydrase II
CALU calumenin
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CAV2 caveolin 2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CENPU centromere protein U
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENO1 enolase 1, (alpha)
FAM57A family with sequence similarity 57, member A
G0S2 G0/G1 switch 2
GALE UDP-galactose-4-epimerase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
IGKV1-5 immunoglobulin kappa variable 1-5
KCTD12 potassium channel tetramerization domain containing 12
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19 keratin 19, type I
LIMCH1 LIM and calponin homology domains 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MLF1 myeloid leukemia factor 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MRPL12 mitochondrial ribosomal protein L12
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NRIP1 nuclear receptor interacting protein 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PCNA proliferating cell nuclear antigen
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEA15 phosphoprotein enriched in astrocytes 15
PFKP phosphofructokinase, platelet
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCB protein kinase C, beta
PRMT1 protein arginine methyltransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAN RAN, member RAS oncogene family
RANBP1 RAN binding protein 1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SQLE squalene epoxidase
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
TCL1A T-cell leukemia/lymphoma 1A
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM45A transmembrane protein 45A
TPM1 tropomyosin 1 (alpha)
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein