BRD-A18328003_GDC-0980_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-A18328003_GDC-0980_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ASS1 argininosuccinate synthase 1
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CEMIP cell migration inducing protein, hyaluronan binding
CEP57 centrosomal protein 57kDa
CLIC5 chloride intracellular channel 5
COMP cartilage oligomeric matrix protein
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTGF connective tissue growth factor
CTSA cathepsin A
CTSK cathepsin K
CYBRD1 cytochrome b reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DARS aspartyl-tRNA synthetase
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DOCK9 dedicator of cytokinesis 9
EIF2D eukaryotic translation initiation factor 2D
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4B eukaryotic translation initiation factor 4B
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ETHE1 ethylmalonic encephalopathy 1
FAM8A1 family with sequence similarity 8, member A1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FNBP1 formin binding protein 1
FXR1 fragile X mental retardation, autosomal homolog 1
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
GSE1 Gse1 coiled-coil protein
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2AC histone cluster 1, H2ac
HIST3H2A histone cluster 3, H2a
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOOK2 hook microtubule-tethering protein 2
IGBP1 immunoglobulin (CD79A) binding protein 1
IGKV1-5 immunoglobulin kappa variable 1-5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITM2A integral membrane protein 2A
KIAA0753 KIAA0753
KIZ kizuna centrosomal protein
LETMD1 LETM1 domain containing 1
LGALS4 lectin, galactoside-binding, soluble, 4
LPIN1 lipin 1
LRPPRC leucine-rich pentatricopeptide repeat containing
LXN latexin
LYZ lysozyme
MAB21L1 mab-21-like 1 (C. elegans)
MGLL monoglyceride lipase
MN1 meningioma (disrupted in balanced translocation) 1
MTUS1 microtubule associated tumor suppressor 1
N4BP2L2 NEDD4 binding protein 2-like 2
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPDC1 neural proliferation, differentiation and control, 1
OBSL1 obscurin-like 1
OPHN1 oligophrenin 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAM peptidylglycine alpha-amidating monooxygenase
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTPRO protein tyrosine phosphatase, receptor type, O
QARS glutaminyl-tRNA synthetase
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS5 regulator of G-protein signaling 5
RPL22 ribosomal protein L22
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
SCD5 stearoyl-CoA desaturase 5
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SETD6 SET domain containing 6
SLC22A18 solute carrier family 22, member 18
SLC35E2B solute carrier family 35, member E2B
SLC38A10 solute carrier family 38, member 10
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SPATA20 spermatogenesis associated 20
SSBP2 single-stranded DNA binding protein 2
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM63A transmembrane protein 63A
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRAF5 TNF receptor-associated factor 5
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TSPAN4 tetraspanin 4
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VWA8 von Willebrand factor A domain containing 8
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
CKS2 CDC28 protein kinase regulatory subunit 2
CSRP2 cysteine and glycine-rich protein 2
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HSPA14 heat shock 70kDa protein 14
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KCTD12 potassium channel tetramerization domain containing 12
KIF14 kinesin family member 14
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMNB1 lamin B1
LSM1 LSM1, U6 small nuclear RNA associated
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MELK maternal embryonic leucine zipper kinase
MICB MHC class I polypeptide-related sequence B
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1E metallothionein 1E
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPH non-SMC condensin I complex, subunit H
NLRP2 NLR family, pyrin domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
RACGAP1 Rac GTPase activating protein 1
RBM47 RNA binding motif protein 47
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SFPQ splicing factor proline/glutamine-rich
SHCBP1 SHC SH2-domain binding protein 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNRPG small nuclear ribonucleoprotein polypeptide G
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
SUB1 SUB1 homolog (S. cerevisiae)
TF transferrin
TMPO thymopoietin
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
UBE2N ubiquitin-conjugating enzyme E2N
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)