BRD-A18328003_GDC-0980_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

196 genes differentially expressed following the BRD-A18328003_GDC-0980_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
AHNAK2 AHNAK nucleoprotein 2
AKAP1 A kinase (PRKA) anchor protein 1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
ASMTL acetylserotonin O-methyltransferase-like
ATM ATM serine/threonine kinase
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP9A ATPase, class II, type 9A
BTF3 basic transcription factor 3
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEMIP cell migration inducing protein, hyaluronan binding
CSNK2A2 casein kinase 2, alpha prime polypeptide
DIAPH2 diaphanous-related formin 2
DST dystonin
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF2 eukaryotic translation elongation factor 2
EIF2D eukaryotic translation initiation factor 2D
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
EPS8 epidermal growth factor receptor pathway substrate 8
ETHE1 ethylmalonic encephalopathy 1
FAM8A1 family with sequence similarity 8, member A1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR4 fibroblast growth factor receptor 4
GATAD1 GATA zinc finger domain containing 1
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GSDMB gasdermin B
GUSBP3 glucuronidase, beta pseudogene 3
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFI6 interferon, alpha-inducible protein 6
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP5 insulin-like growth factor binding protein 5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LRRC37A3 leucine rich repeat containing 37, member A3
MET MET proto-oncogene, receptor tyrosine kinase
MYLK myosin light chain kinase
NONO non-POU domain containing, octamer-binding
NOV nephroblastoma overexpressed
NPDC1 neural proliferation, differentiation and control, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFM4 olfactomedin 4
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAM peptidylglycine alpha-amidating monooxygenase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PGLS 6-phosphogluconolactonase
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PTPRO protein tyrosine phosphatase, receptor type, O
QARS glutaminyl-tRNA synthetase
RBPMS RNA binding protein with multiple splicing
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL28 ribosomal protein L28
RPL36 ribosomal protein L36
RSL1D1 ribosomal L1 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC35E1 solute carrier family 35, member E1
SOD2 superoxide dismutase 2, mitochondrial
SPATA20 spermatogenesis associated 20
SSFA2 sperm specific antigen 2
SSPN sarcospan
SULF1 sulfatase 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR3 transforming growth factor, beta receptor III
THBS2 thrombospondin 2
TMEM63A transmembrane protein 63A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPCN1 two pore segment channel 1
TRAF5 TNF receptor-associated factor 5
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
UXT ubiquitously-expressed, prefoldin-like chaperone
VWA8 von Willebrand factor A domain containing 8
ZNF277 zinc finger protein 277
ZNF451 zinc finger protein 451
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CRABP2 cellular retinoic acid binding protein 2
CREB1 cAMP responsive element binding protein 1
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLIPR1 GLI pathogenesis-related 1
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGKV4-1 immunoglobulin kappa variable 4-1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KCTD12 potassium channel tetramerization domain containing 12
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMNB1 lamin B1
LMNB2 lamin B2
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEK2 NIMA-related kinase 2
NRGN neurogranin (protein kinase C substrate, RC3)
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAD23B RAD23 homolog B (S. cerevisiae)
RBM47 RNA binding motif protein 47
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCAN1 regulator of calcineurin 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RIT1 Ras-like without CAAX 1
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SNN stannin
SPC25 SPC25, NDC80 kinetochore complex component
SRGN serglycin
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
TRA2B transformer 2 beta homolog (Drosophila)
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S