BRD-A18328003_GDC-0980_A375_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

182 genes differentially expressed following the BRD-A18328003_GDC-0980_A375_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA1 annexin A1
ANXA4 annexin A4
APOD apolipoprotein D
ATM ATM serine/threonine kinase
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BTF3 basic transcription factor 3
C1S complement component 1, s subcomponent
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEP57 centrosomal protein 57kDa
CFB complement factor B
CFH complement factor H
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSK cathepsin K
DARS aspartyl-tRNA synthetase
DCN decorin
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EHBP1 EH domain binding protein 1
EIF2D eukaryotic translation initiation factor 2D
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF3E eukaryotic translation initiation factor 3, subunit E
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4B eukaryotic translation initiation factor 4B
EMP1 epithelial membrane protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB3 erb-b2 receptor tyrosine kinase 3
ERGIC3 ERGIC and golgi 3
ESD esterase D
FAM63A family with sequence similarity 63, member A
FAR2 fatty acyl CoA reductase 2
FXR1 fragile X mental retardation, autosomal homolog 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSDMB gasdermin B
HDAC9 histone deacetylase 9
HIST1H2AC histone cluster 1, H2ac
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGA2 high mobility group AT-hook 2
IFI6 interferon, alpha-inducible protein 6
IGBP1 immunoglobulin (CD79A) binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO7 importin 7
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KDSR 3-ketodihydrosphingosine reductase
KIAA0753 KIAA0753
LAMC2 laminin, gamma 2
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRPPRC leucine-rich pentatricopeptide repeat containing
LTA4H leukotriene A4 hydrolase
MAB21L1 mab-21-like 1 (C. elegans)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANSC1 MANSC domain containing 1
MET MET proto-oncogene, receptor tyrosine kinase
MOAP1 modulator of apoptosis 1
MTMR11 myotubularin related protein 11
MX2 MX dynamin-like GTPase 2
MYO5C myosin VC
NAP1L1 nucleosome assembly protein 1-like 1
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NET1 neuroepithelial cell transforming 1
NONO non-POU domain containing, octamer-binding
NPDC1 neural proliferation, differentiation and control, 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPHN1 oligophrenin 1
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
QARS glutaminyl-tRNA synthetase
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS5 regulator of G-protein signaling 5
RNASE4 ribonuclease, RNase A family, 4
RPL13 ribosomal protein L13
RPL15 ribosomal protein L15
RPL22 ribosomal protein L22
RPL28 ribosomal protein L28
RPL31 ribosomal protein L31
RPL36 ribosomal protein L36
RPS17 ribosomal protein S17
RPS25 ribosomal protein S25
RSL1D1 ribosomal L1 domain containing 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SOD2 superoxide dismutase 2, mitochondrial
SSFA2 sperm specific antigen 2
SSPN sarcospan
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SVIL supervillin
TFPI2 tissue factor pathway inhibitor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TMC5 transmembrane channel-like 5
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TSPAN4 tetraspanin 4
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VWA8 von Willebrand factor A domain containing 8
ZNF277 zinc finger protein 277
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARG2 arginase 2
AURKA aurora kinase A
BMP4 bone morphogenetic protein 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CCNA2 cyclin A2
CDC42 cell division cycle 42
CHEK2 checkpoint kinase 2
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
CXCL6 chemokine (C-X-C motif) ligand 6
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHCR24 24-dehydrocholesterol reductase
FGFR3 fibroblast growth factor receptor 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GSTA1 glutathione S-transferase alpha 1
HMOX1 heme oxygenase 1
HSPA14 heat shock 70kDa protein 14
HSPB8 heat shock 22kDa protein 8
HYOU1 hypoxia up-regulated 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KRT19 keratin 19, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LMNB1 lamin B1
LTF lactotransferrin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1E metallothionein 1E
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYLK myosin light chain kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NLRP2 NLR family, pyrin domain containing 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5DC2 5'-nucleotidase domain containing 2
PARP2 poly (ADP-ribose) polymerase 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHGDH phosphoglycerate dehydrogenase
PLEK pleckstrin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIT1 Ras-like without CAAX 1
RRM2 ribonucleotide reductase M2
SDF2L1 stromal cell-derived factor 2-like 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SRGN serglycin
TSPAN13 tetraspanin 13
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)