BRD-A18202423_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-A18202423_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
BTG2 BTG family, member 2
C3 complement component 3
CD163 CD163 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DLK1 delta-like 1 homolog (Drosophila)
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXT1 exostosin glycosyltransferase 1
EZR ezrin
FBLN1 fibulin 1
FGF9 fibroblast growth factor 9
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
JCHAIN joining chain of multimeric IgA and IgM
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
MAN2A1 mannosidase, alpha, class 2A, member 1
MMP7 matrix metallopeptidase 7
MPZL2 myelin protein zero-like 2
MT1E metallothionein 1E
NRGN neurogranin (protein kinase C substrate, RC3)
ORC1 origin recognition complex, subunit 1
PEA15 phosphoprotein enriched in astrocytes 15
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCL1 phospholipase C-like 1
PLIN2 perilipin 2
PRSS16 protease, serine, 16 (thymus)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSU1 Ras suppressor protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SELENBP1 selenium binding protein 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFTPB surfactant protein B
SOD2 superoxide dismutase 2, mitochondrial
SOSTDC1 sclerostin domain containing 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
BASP1 brain abundant, membrane attached signal protein 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CBR3 carbonyl reductase 3
COL1A1 collagen, type I, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF5A eukaryotic translation initiation factor 5A
G0S2 G0/G1 switch 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXC6 homeobox C6
NME4 NME/NM23 nucleoside diphosphate kinase 4
PCDH9 protocadherin 9
PLAC8 placenta-specific 8
POPDC3 popeye domain containing 3
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTGES prostaglandin E synthase
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SET SET nuclear proto-oncogene
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPO translocator protein (18kDa)
WWP1 WW domain containing E3 ubiquitin protein ligase 1