BRD-A17819071_DEACETOXY-7-OXISOGEDUNIN_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-A17819071_DEACETOXY-7-OXISOGEDUNIN_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMPD3 adenosine monophosphate deaminase 3
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CCND1 cyclin D1
CDCP1 CUB domain containing protein 1
CLEC2B C-type lectin domain family 2, member B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HDAC9 histone deacetylase 9
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
KYNU kynureninase
LCN2 lipocalin 2
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP3 nuclear receptor interacting protein 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PPAP2C phosphatidic acid phosphatase type 2C
PTPRO protein tyrosine phosphatase, receptor type, O
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS10 regulator of G-protein signaling 10
RIN3 Ras and Rab interactor 3
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TXN thioredoxin
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ADA adenosine deaminase
ADAM10 ADAM metallopeptidase domain 10
ADAM12 ADAM metallopeptidase domain 12
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASCL1 achaete-scute family bHLH transcription factor 1
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CLIC3 chloride intracellular channel 3
COL5A1 collagen, type V, alpha 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EPHA3 EPH receptor A3
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL1 four and a half LIM domains 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LUM lumican
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
OLFML2B olfactomedin-like 2B
PLAGL1 pleiomorphic adenoma gene-like 1
PPAP2A phosphatidic acid phosphatase type 2A
QKI QKI, KH domain containing, RNA binding
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN1 regulator of calcineurin 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SULF1 sulfatase 1
TLE4 transducin-like enhancer of split 4
TM7SF2 transmembrane 7 superfamily member 2
TMEM47 transmembrane protein 47
TMPRSS2 transmembrane protease, serine 2
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TTC3 tetratricopeptide repeat domain 3
VCAN versican