BRD-A17428743_BW 723C86 hydrochloride_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-A17428743_BW 723C86 hydrochloride_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CFD complement factor D (adipsin)
CHI3L2 chitinase 3-like 2
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COBL cordon-bleu WH2 repeat protein
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DMTF1 cyclin D binding myb-like transcription factor 1
EBP emopamil binding protein (sterol isomerase)
EI24 etoposide induced 2.4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FGF13 fibroblast growth factor 13
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXC1 forkhead box C1
FUCA1 fucosidase, alpha-L- 1, tissue
GLUL glutamate-ammonia ligase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
KRT4 keratin 4, type II
LTF lactotransferrin
MAB21L2 mab-21-like 2 (C. elegans)
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MSX1 msh homeobox 1
NFIB nuclear factor I/B
NRN1 neuritin 1
PDLIM5 PDZ and LIM domain 5
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SVIL supervillin
SYNM synemin, intermediate filament protein
TCAF1 TRPM8 channel-associated factor 1
TNC tenascin C
TPD52L1 tumor protein D52-like 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPK1B uroplakin 1B
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ANXA4 annexin A4
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARMCX2 armadillo repeat containing, X-linked 2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DPP4 dipeptidyl-peptidase 4
EPHA3 EPH receptor A3
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FLRT3 fibronectin leucine rich transmembrane protein 3
GJA1 gap junction protein, alpha 1, 43kDa
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
JAM3 junctional adhesion molecule 3
MMP2 matrix metallopeptidase 2
NEFH neurofilament, heavy polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NID1 nidogen 1
NNMT nicotinamide N-methyltransferase
NXN nucleoredoxin
P3H2 prolyl 3-hydroxylase 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRKCI protein kinase C, iota
RNASE6 ribonuclease, RNase A family, k6
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SHB Src homology 2 domain containing adaptor protein B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPAG16 sperm associated antigen 16
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TOX thymocyte selection-associated high mobility group box
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WBP5 WW domain binding protein 5