BRD-A17065207_Brefeldin A_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-A17065207_Brefeldin A_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
CALU calumenin
CARS cysteinyl-tRNA synthetase
CCL2 chemokine (C-C motif) ligand 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CREB3L2 cAMP responsive element binding protein 3-like 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELANE elastase, neutrophil expressed
EPRS glutamyl-prolyl-tRNA synthetase
FKBP11 FK506 binding protein 11, 19 kDa
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
GUSBP11 glucuronidase, beta pseudogene 11
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOOK2 hook microtubule-tethering protein 2
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT7 keratin 7, type II
MAGED1 melanoma antigen family D1
MANF mesencephalic astrocyte-derived neurotrophic factor
MARS methionyl-tRNA synthetase
MED8 mediator complex subunit 8
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYDGF myeloid-derived growth factor
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NUCB2 nucleobindin 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RAD9A RAD9 homolog A (S. pombe)
SARS seryl-tRNA synthetase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEC13 SEC13 homolog (S. cerevisiae)
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35B1 solute carrier family 35, member B1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
STC2 stanniocalcin 2
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
ZCCHC8 zinc finger, CCHC domain containing 8

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
BAD BCL2-associated agonist of cell death
CCND1 cyclin D1
COL4A6 collagen, type IV, alpha 6
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
ITGB5 integrin, beta 5
KDM5D lysine (K)-specific demethylase 5D
LYPLA1 lysophospholipase I
MARCKSL1 MARCKS-like 1
MCM5 minichromosome maintenance complex component 5
MPZL1 myelin protein zero-like 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PNMA1 paraneoplastic Ma antigen 1
PODXL podocalyxin-like
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TSPAN3 tetraspanin 3
TUBB4B tubulin, beta 4B class IVb
USP9Y ubiquitin specific peptidase 9, Y-linked