BRD-A17065207_Brefeldin A_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

221 genes differentially expressed following the BRD-A17065207_Brefeldin A_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AIM2 absent in melanoma 2
AKAP9 A kinase (PRKA) anchor protein 9
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA10 annexin A10
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARG1 arginase 1
ARMCX3 armadillo repeat containing, X-linked 3
BHLHE41 basic helix-loop-helix family, member e41
CALU calumenin
CARS cysteinyl-tRNA synthetase
CCPG1 cell cycle progression 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CYBB cytochrome b-245, beta polypeptide
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPH2 DPH2 homolog (S. cerevisiae)
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP7 fatty acid binding protein 7, brain
FKBP11 FK506 binding protein 11, 19 kDa
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
GATAD1 GATA zinc finger domain containing 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GSTP1 glutathione S-transferase pi 1
HSPA13 heat shock protein 70kDa family, member 13
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFT20 intraflagellar transport 20
IGKV4-1 immunoglobulin kappa variable 4-1
IQCG IQ motif containing G
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JMJD6 jumonji domain containing 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT14 keratin 14, type I
MAGEH1 melanoma antigen family H1
MT1E metallothionein 1E
MXI1 MAX interactor 1, dimerization protein
NDNF neuron-derived neurotrophic factor
OPTN optineurin
OSBPL2 oxysterol binding protein-like 2
PAIP2B poly(A) binding protein interacting protein 2B
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PXDC1 PX domain containing 1
RAD9A RAD9 homolog A (S. pombe)
SCGB2A2 secretoglobin, family 2A, member 2
SEC24D SEC24 family member D
SERP1 stress-associated endoplasmic reticulum protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A2 solute carrier family 38, member 2
SLC43A3 solute carrier family 43, member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
THBS2 thrombospondin 2
TM9SF2 transmembrane 9 superfamily member 2
TMEM208 transmembrane protein 208
TMEM39A transmembrane protein 39A
TUBA4A tubulin, alpha 4a
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
VCAN versican
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNT5A wingless-type MMTV integration site family, member 5A
YIPF5 Yip1 domain family, member 5
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACACA acetyl-CoA carboxylase alpha
ACLY ATP citrate lyase
ACPP acid phosphatase, prostate
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
AHCY adenosylhomocysteinase
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APLP2 amyloid beta (A4) precursor-like protein 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
CAPNS1 calpain, small subunit 1
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CCNG1 cyclin G1
CCNI cyclin I
CD320 CD320 molecule
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CKB creatine kinase, brain
CKS2 CDC28 protein kinase regulatory subunit 2
CLSTN1 calsyntenin 1
COCH cochlin
CST3 cystatin C
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DHRS7 dehydrogenase/reductase (SDR family) member 7
ECM1 extracellular matrix protein 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ETFB electron-transfer-flavoprotein, beta polypeptide
FADS2 fatty acid desaturase 2
FAM171A1 family with sequence similarity 171, member A1
FASN fatty acid synthase
FAT1 FAT atypical cadherin 1
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOXA1 forkhead box A1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
GLB1L2 galactosidase, beta 1-like 2
GLRX glutaredoxin (thioltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
GSE1 Gse1 coiled-coil protein
GSTM3 glutathione S-transferase mu 3 (brain)
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HOMER2 homer scaffolding protein 2
HOXA10 homeobox A10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KIF20A kinesin family member 20A
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
L1CAM L1 cell adhesion molecule
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LMNB1 lamin B1
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MLPH melanophilin
MMD monocyte to macrophage differentiation-associated
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NEFH neurofilament, heavy polypeptide
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPDC1 neural proliferation, differentiation and control, 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCCB propionyl CoA carboxylase, beta polypeptide
PLAC8 placenta-specific 8
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPAP2A phosphatidic acid phosphatase type 2A
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSD3 pleckstrin and Sec7 domain containing 3
PUF60 poly-U binding splicing factor 60KDa
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP1GAP RAP1 GTPase activating protein
RCC1 regulator of chromosome condensation 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS10 regulator of G-protein signaling 10
RPL22 ribosomal protein L22
RPL37A ribosomal protein L37a
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
SC5D sterol-C5-desaturase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQLE squalene epoxidase
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST7 suppression of tumorigenicity 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK26 serine/threonine protein kinase 26
STMN1 stathmin 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TKT transketolase
TMEM14A transmembrane protein 14A
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TST thiosulfate sulfurtransferase (rhodanese)
ZFP36L1 ZFP36 ring finger protein-like 1