BRD-A17065207_Brefeldin A_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

349 genes differentially expressed following the BRD-A17065207_Brefeldin A_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACBD3 acyl-CoA binding domain containing 3
AKAP9 A kinase (PRKA) anchor protein 9
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
C2CD2L C2CD2-like
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCDC176 coiled-coil domain containing 176
CCDC28A coiled-coil domain containing 28A
CCNA1 cyclin A1
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLINT1 clathrin interactor 1
COPA coatomer protein complex, subunit alpha
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3A fibronectin type III domain containing 3A
FNDC3B fibronectin type III domain containing 3B
FOXO4 forkhead box O4
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLGA5 golgin A5
GOLGB1 golgin B1
GOLT1B golgi transport 1B
GORASP2 golgi reassembly stacking protein 2, 55kDa
GPM6B glycoprotein M6B
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
ICAM3 intercellular adhesion molecule 3
IFT20 intraflagellar transport 20
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIZ kizuna centrosomal protein
LMBRD1 LMBR1 domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
MAGEH1 melanoma antigen family H1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MED8 mediator complex subunit 8
METTL7A methyltransferase like 7A
MICALL1 MICAL-like 1
MPC1 mitochondrial pyruvate carrier 1
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLGN4X neuroligin 4, X-linked
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PER1 period circadian clock 1
PHF1 PHD finger protein 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
POU2AF1 POU class 2 associating factor 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB5A RAB5A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RRBP1 ribosome binding protein 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCRG1 stimulator of chondrogenesis 1
SEC23B Sec23 homolog B (S. cerevisiae)
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SQSTM1 sequestosome 1
SRPR signal recognition particle receptor (docking protein)
SSR1 signal sequence receptor, alpha
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SUCO SUN domain containing ossification factor
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TERT telomerase reverse transcriptase
TM9SF2 transmembrane 9 superfamily member 2
TXNDC15 thioredoxin domain containing 15
TXNIP thioredoxin interacting protein
USO1 USO1 vesicle transport factor
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
YIPF3 Yip1 domain family, member 3
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2A1 BCL2-related protein A1
BIK BCL2-interacting killer (apoptosis-inducing)
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHRDL1 chordin-like 1
CKAP2 cytoskeleton associated protein 2
CNN3 calponin 3, acidic
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSZ cathepsin Z
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD2 EF-hand domain family, member D2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP2 epithelial membrane protein 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENG endoglin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM111A family with sequence similarity 111, member A
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FAT1 FAT atypical cadherin 1
FEN1 flap structure-specific endonuclease 1
FERMT1 fermitin family member 1
FLNA filamin A, alpha
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXM1 forkhead box M1
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GTSE1 G-2 and S-phase expressed 1
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMA3 laminin, alpha 3
LAP3 leucine aminopeptidase 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LMNB2 lamin B2
LTB lymphotoxin beta (TNF superfamily, member 3)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MTERF3 mitochondrial transcription termination factor 3
MTF2 metal response element binding transcription factor 2
MYH11 myosin, heavy chain 11, smooth muscle
NAP1L1 nucleosome assembly protein 1-like 1
NAV3 neuron navigator 3
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPG non-SMC condensin I complex, subunit G
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NFE2L3 nuclear factor, erythroid 2-like 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKX3-1 NK3 homeobox 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PEBP1 phosphatidylethanolamine binding protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKM pyruvate kinase, muscle
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PLXNA1 plexin A1
PMEPA1 prostate transmembrane protein, androgen induced 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RBP1 retinol binding protein 1, cellular
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SET SET nuclear proto-oncogene
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD3 SMAD family member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPC25 SPC25, NDC80 kinetochore complex component
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TFDP1 transcription factor Dp-1
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM164 transmembrane protein 164
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMSB15A thymosin beta 15a
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZWINT ZW10 interacting kinetochore protein