BRD-A17065207_Brefeldin A_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-A17065207_Brefeldin A_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADAMDEC1 ADAM-like, decysin 1
AIM2 absent in melanoma 2
AKAP9 A kinase (PRKA) anchor protein 9
ALOX5 arachidonate 5-lipoxygenase
ARF4 ADP-ribosylation factor 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CCND2 cyclin D2
CD48 CD48 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CRELD2 cysteine-rich with EGF-like domains 2
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DUSP6 dual specificity phosphatase 6
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPRS glutamyl-prolyl-tRNA synthetase
FAM8A1 family with sequence similarity 8, member A1
FBXO11 F-box protein 11
FKBP11 FK506 binding protein 11, 19 kDa
FST follistatin
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LRRC59 leucine rich repeat containing 59
MANF mesencephalic astrocyte-derived neurotrophic factor
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARS methionyl-tRNA synthetase
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO5C myosin VC
MZB1 marginal zone B and B1 cell-specific protein
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POU2AF1 POU class 2 associating factor 1
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SERP1 stress-associated endoplasmic reticulum protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQRDL sulfide quinone reductase-like (yeast)
SRPRB signal recognition particle receptor, B subunit
STC2 stanniocalcin 2
TBL2 transducin (beta)-like 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
ZCCHC8 zinc finger, CCHC domain containing 8

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACTB actin, beta
AFF1 AF4/FMR2 family, member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
C16ORF45 chromosome 16 open reading frame 45
C1R complement component 1, r subcomponent
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
COL4A5 collagen, type IV, alpha 5
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EID1 EP300 interacting inhibitor of differentiation 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENG endoglin
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FLNA filamin A, alpha
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLCE glucuronic acid epimerase
GLIPR1 GLI pathogenesis-related 1
GOLM1 golgi membrane protein 1
HMGN3 high mobility group nucleosomal binding domain 3
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IL1R1 interleukin 1 receptor, type I
IL32 interleukin 32
LAMB1 laminin, beta 1
LOXL1 lysyl oxidase-like 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MXRA5 matrix-remodelling associated 5
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PALLD palladin, cytoskeletal associated protein
PRSS23 protease, serine, 23
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SDC2 syndecan 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SORD sorbitol dehydrogenase
SRPX2 sushi-repeat containing protein, X-linked 2
SUMO2 small ubiquitin-like modifier 2
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM9SF3 transmembrane 9 superfamily member 3
TMEM164 transmembrane protein 164
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TXNDC9 thioredoxin domain containing 9
WNT5A wingless-type MMTV integration site family, member 5A
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta