BRD-A17065207_Brefeldin A_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

326 genes differentially expressed following the BRD-A17065207_Brefeldin A_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY2 adenylate cyclase 2 (brain)
AKAP9 A kinase (PRKA) anchor protein 9
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BET1 Bet1 golgi vesicular membrane trafficking protein
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CCDC28A coiled-coil domain containing 28A
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COBL cordon-bleu WH2 repeat protein
COPA coatomer protein complex, subunit alpha
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
CYB561 cytochrome b561
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHDDS dehydrodolichyl diphosphate synthase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FKBP11 FK506 binding protein 11, 19 kDa
GLRX glutaredoxin (thioltransferase)
GOLGB1 golgin B1
GOLT1B golgi transport 1B
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HOPX HOP homeobox
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
ICAM3 intercellular adhesion molecule 3
IFNGR1 interferon gamma receptor 1
IFT20 intraflagellar transport 20
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ISCU iron-sulfur cluster assembly enzyme
KIAA0513 KIAA0513
KLHDC2 kelch domain containing 2
KYNU kynureninase
MAGEH1 melanoma antigen family H1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MPC1 mitochondrial pyruvate carrier 1
MUC4 mucin 4, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MZB1 marginal zone B and B1 cell-specific protein
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL2 oxysterol binding protein-like 2
PEG3 paternally expressed 3
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RBKS ribokinase
RGCC regulator of cell cycle
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEC63 SEC63 homolog (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM7 small integral membrane protein 7
SNAP25 synaptosomal-associated protein, 25kDa
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
SRPRB signal recognition particle receptor, B subunit
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBC1D15 TBC1 domain family, member 15
TDO2 tryptophan 2,3-dioxygenase
TERF2IP telomeric repeat binding factor 2, interacting protein
TM9SF2 transmembrane 9 superfamily member 2
TMEM208 transmembrane protein 208
TMEM231 transmembrane protein 231
TRIB3 tribbles pseudokinase 3
TXNL4B thioredoxin-like 4B
WARS tryptophanyl-tRNA synthetase
WDR19 WD repeat domain 19
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WWOX WW domain containing oxidoreductase

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSF2 acyl-CoA synthetase family member 2
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTB actin, beta
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ADA adenosine deaminase
ADAM19 ADAM metallopeptidase domain 19
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AGRN agrin
AHNAK AHNAK nucleoprotein
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALB albumin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
ANXA2P2 annexin A2 pseudogene 2
ANXA3 annexin A3
AOX1 aldehyde oxidase 1
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
AXL AXL receptor tyrosine kinase
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BICC1 BicC family RNA binding protein 1
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD24 CD24 molecule
CD320 CD320 molecule
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDCA3 cell division cycle associated 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COTL1 coactosin-like F-actin binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPEP1 dipeptidase 1 (renal)
DSTN destrin (actin depolymerizing factor)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHD1 EH-domain containing 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP2 epithelial membrane protein 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENG endoglin
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHB2 EPH receptor B2
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAT1 FAT atypical cadherin 1
FBN1 fibrillin 1
FERMT2 fermitin family member 2
FHL2 four and a half LIM domains 2
FLNA filamin A, alpha
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HEG1 heart development protein with EGF-like domains 1
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB6 homeobox B6
HOXB7 homeobox B7
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB5 integrin, beta 5
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
L1CAM L1 cell adhesion molecule
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LASP1 LIM and SH3 protein 1
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGMN legumain
LMCD1 LIM and cysteine-rich domains 1
LOC100505650 uncharacterized LOC100505650
LOXL1 lysyl oxidase-like 1
LTBP2 latent transforming growth factor beta binding protein 2
MAB21L2 mab-21-like 2 (C. elegans)
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NBL1 neuroblastoma 1, DAN family BMP antagonist
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OXTR oxytocin receptor
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAX8 paired box 8
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PCYOX1 prenylcysteine oxidase 1
PDGFC platelet derived growth factor C
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PKM pyruvate kinase, muscle
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS3 plastin 3
PMEPA1 prostate transmembrane protein, androgen induced 1
PODXL podocalyxin-like
PRSS23 protease, serine, 23
RAB3B RAB3B, member RAS oncogene family
RALB v-ral simian leukemia viral oncogene homolog B
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SACS sacsin molecular chaperone
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SDPR serum deprivation response
SEPT11 septin 11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAGP small cell adhesion glycoprotein
SMS spermine synthase
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM164 transmembrane protein 164
TMEM2 transmembrane protein 2
TMPO thymopoietin
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOMM34 translocase of outer mitochondrial membrane 34
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican
VCL vinculin
WWTR1 WW domain containing transcription regulator 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZWINT ZW10 interacting kinetochore protein