BRD-A17065207_-666_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

329 genes differentially expressed following the BRD-A17065207_-666_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP9 aquaporin 9
ARCN1 archain 1
ARF4 ADP-ribosylation factor 4
ARFIP2 ADP-ribosylation factor interacting protein 2
ARL1 ADP-ribosylation factor-like 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF6 activating transcription factor 6
ATG3 autophagy related 3
BCAS2 breast carcinoma amplified sequence 2
BET1 Bet1 golgi vesicular membrane trafficking protein
CCDC28A coiled-coil domain containing 28A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CLDN3 claudin 3
CLINT1 clathrin interactor 1
CLU clusterin
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COASY CoA synthase
COPB1 coatomer protein complex, subunit beta 1
CP ceruloplasmin (ferroxidase)
CUTA cutA divalent cation tolerance homolog (E. coli)
CXADR coxsackie virus and adenovirus receptor
CYB561 cytochrome b561
CYBB cytochrome b-245, beta polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPTOR DEP domain containing MTOR-interacting protein
DHDDS dehydrodolichyl diphosphate synthase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPH2 DPH2 homolog (S. cerevisiae)
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPRS glutamyl-prolyl-tRNA synthetase
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FKBP11 FK506 binding protein 11, 19 kDa
GOLT1B golgi transport 1B
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HP haptoglobin
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA13 heat shock protein 70kDa family, member 13
HSPA9 heat shock 70kDa protein 9 (mortalin)
ICAM3 intercellular adhesion molecule 3
IFRD1 interferon-related developmental regulator 1
IFT20 intraflagellar transport 20
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IQCG IQ motif containing G
IQCK IQ motif containing K
IQGAP2 IQ motif containing GTPase activating protein 2
JMJD6 jumonji domain containing 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLHDC2 kelch domain containing 2
LAGE3 L antigen family, member 3
LCN2 lipocalin 2
LONP1 lon peptidase 1, mitochondrial
LTF lactotransferrin
LZTFL1 leucine zipper transcription factor-like 1
MALT1 MALT1 paracaspase
MED8 mediator complex subunit 8
MLEC malectin
MPC1 mitochondrial pyruvate carrier 1
MUT methylmalonyl CoA mutase
MXI1 MAX interactor 1, dimerization protein
MYDGF myeloid-derived growth factor
MZB1 marginal zone B and B1 cell-specific protein
NANS N-acetylneuraminic acid synthase
NARS asparaginyl-tRNA synthetase
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEBL nebulette
NME7 NME/NM23 family member 7
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDZK1IP1 PDZK1 interacting protein 1
PER2 period circadian clock 2
POU2AF1 POU class 2 associating factor 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD9A RAD9 homolog A (S. pombe)
RANBP6 RAN binding protein 6
RBKS ribokinase
RBM47 RNA binding motif protein 47
RNF167 ring finger protein 167
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RTN3 reticulon 3
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRPR signal recognition particle receptor (docking protein)
SRPRB signal recognition particle receptor, B subunit
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBC1D15 TBC1 domain family, member 15
TBL2 transducin (beta)-like 2
TM9SF2 transmembrane 9 superfamily member 2
TMEM231 transmembrane protein 231
TREM1 triggering receptor expressed on myeloid cells 1
TXNL4B thioredoxin-like 4B
UFM1 ubiquitin-fold modifier 1
UQCRH ubiquinol-cytochrome c reductase hinge protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
YME1L1 YME1-like 1 ATPase

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACTN1 actinin, alpha 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRE5 adhesion G protein-coupled receptor E5
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AHNAK AHNAK nucleoprotein
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
AKAP7 A kinase (PRKA) anchor protein 7
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPN asporin
AXL AXL receptor tyrosine kinase
BCHE butyrylcholinesterase
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
C3ORF14 chromosome 3 open reading frame 14
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCNG2 cyclin G2
CD9 CD9 molecule
CD99 CD99 molecule
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CELF2 CUGBP, Elav-like family member 2
CNN3 calponin 3, acidic
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
COPS7A COP9 signalosome subunit 7A
CORO1C coronin, actin binding protein, 1C
CSPG4 chondroitin sulfate proteoglycan 4
CSRP2 cysteine and glycine-rich protein 2
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENG endoglin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
F2R coagulation factor II (thrombin) receptor
FAM171A1 family with sequence similarity 171, member A1
FAT1 FAT atypical cadherin 1
FERMT1 fermitin family member 1
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FLNA filamin A, alpha
FRY furry homolog (Drosophila)
FST follistatin
FSTL1 follistatin-like 1
GPC1 glypican 1
GPX3 glutathione peroxidase 3
GRK5 G protein-coupled receptor kinase 5
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOMER3 homer scaffolding protein 3
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPG2 heparan sulfate proteoglycan 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGB5 integrin, beta 5
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LIMA1 LIM domain and actin binding 1
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LMNA lamin A/C
LOXL1 lysyl oxidase-like 1
LTBP2 latent transforming growth factor beta binding protein 2
MAPK1 mitogen-activated protein kinase 1
MARCKSL1 MARCKS-like 1
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MEF2C myocyte enhancer factor 2C
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP11 matrix metallopeptidase 11
MMP2 matrix metallopeptidase 2
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
MYH9 myosin, heavy chain 9, non-muscle
MYLK myosin light chain kinase
MYO10 myosin X
NEB nebulin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5E 5'-nucleotidase, ecto (CD73)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGAP3 post-GPI attachment to proteins 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLXNA1 plexin A1
PON2 paraoxonase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS23 protease, serine, 23
PSD3 pleckstrin and Sec7 domain containing 3
PXDN peroxidasin
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB31 RAB31, member RAS oncogene family
RBMS1 RNA binding motif, single stranded interacting protein 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RHOC ras homolog family member C
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A4 S100 calcium binding protein A4
SASH1 SAM and SH3 domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
SEPW1 selenoprotein W, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFXN3 sideroflexin 3
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPRY4 sprouty homolog 4 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
SUSD5 sushi domain containing 5
SYNGR1 synaptogyrin 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM50A transmembrane protein 50A
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TRAM2 translocation associated membrane protein 2
TTN titin
TUBB6 tubulin, beta 6 class V
TWSG1 twisted gastrulation BMP signaling modulator 1
UPK1B uroplakin 1B
VCAN versican
VCL vinculin
WSB1 WD repeat and SOCS box containing 1
WSB2 WD repeat and SOCS box containing 2
WWTR1 WW domain containing transcription regulator 1
ZFP36L1 ZFP36 ring finger protein-like 1