BRD-A17065207_-666_NEU_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

291 genes differentially expressed following the BRD-A17065207_-666_NEU_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
AHCYL1 adenosylhomocysteinase-like 1
AKAP17A A kinase (PRKA) anchor protein 17A
ALCAM activated leukocyte cell adhesion molecule
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDOA aldolase A, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ARF4 ADP-ribosylation factor 4
ARL1 ADP-ribosylation factor-like 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUD31 BUD31 homolog (S. cerevisiae)
C11ORF24 chromosome 11 open reading frame 24
C20ORF24 chromosome 20 open reading frame 24
CALU calumenin
CARS cysteinyl-tRNA synthetase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHERP calcium homeostasis endoplasmic reticulum protein
CKAP4 cytoskeleton-associated protein 4
COPA coatomer protein complex, subunit alpha
COPB1 coatomer protein complex, subunit beta 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CREB3L2 cAMP responsive element binding protein 3-like 2
CRISP3 cysteine-rich secretory protein 3
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPH2 DPH2 homolog (S. cerevisiae)
DUSP5 dual specificity phosphatase 5
EBNA1BP2 EBNA1 binding protein 2
EGR1 early growth response 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GARS glycyl-tRNA synthetase
GBP1 guanylate binding protein 1, interferon-inducible
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLGA3 golgin A3
GOLT1B golgi transport 1B
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPX7 glutathione peroxidase 7
GSTP1 glutathione S-transferase pi 1
GUSBP11 glucuronidase, beta pseudogene 11
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL6R interleukin 6 receptor
INPP1 inositol polyphosphate-1-phosphatase
ISCU iron-sulfur cluster assembly enzyme
JMJD6 jumonji domain containing 6
JTB jumping translocation breakpoint
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0226 KIAA0226
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LOX lysyl oxidase
LRRC59 leucine rich repeat containing 59
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALT1 MALT1 paracaspase
MAP2K3 mitogen-activated protein kinase kinase 3
MARS methionyl-tRNA synthetase
MED8 mediator complex subunit 8
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MLEC malectin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
MYDGF myeloid-derived growth factor
NARS asparaginyl-tRNA synthetase
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUCB2 nucleobindin 2
NUP98 nucleoporin 98kDa
P4HB prolyl 4-hydroxylase, beta polypeptide
PER2 period circadian clock 2
PHGDH phosphoglycerate dehydrogenase
PITX1 paired-like homeodomain 1
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POU2AF1 POU class 2 associating factor 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PYCR1 pyrroline-5-carboxylate reductase 1
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RB1 retinoblastoma 1
RNF167 ring finger protein 167
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SEC13 SEC13 homolog (S. cerevisiae)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24A SEC24 family member A
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC43A3 solute carrier family 43, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPATS2L spermatogenesis associated, serine-rich 2-like
SQSTM1 sequestosome 1
SRGN serglycin
SRP72 signal recognition particle 72kDa
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
SYNGR2 synaptogyrin 2
TARS threonyl-tRNA synthetase
TGM2 transglutaminase 2
TM9SF2 transmembrane 9 superfamily member 2
TMED2 transmembrane emp24 domain trafficking protein 2
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM87A transmembrane protein 87A
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSTA3 tissue specific transplantation antigen P35B
TUBA4A tubulin, alpha 4a
TWF2 twinfilin actin binding protein 2
TXNL4B thioredoxin-like 4B
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UQCRH ubiquinol-cytochrome c reductase hinge protein
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YIF1A Yip1 interacting factor homolog A (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ARID1A AT rich interactive domain 1A (SWI-like)
ARL4C ADP-ribosylation factor-like 4C
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CCNB2 cyclin B2
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD69 CD69 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEP68 centrosomal protein 68kDa
COL11A1 collagen, type XI, alpha 1
COL2A1 collagen, type II, alpha 1
COLEC12 collectin sub-family member 12
CSRP2 cysteine and glycine-rich protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
DKK2 dickkopf WNT signaling pathway inhibitor 2
DLC1 DLC1 Rho GTPase activating protein
DNASE1L3 deoxyribonuclease I-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA3 EPH receptor A3
EPHA4 EPH receptor A4
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXF1 forkhead box F1
FOXG1 forkhead box G1
FRZB frizzled-related protein
FXYD3 FXYD domain containing ion transport regulator 3
FZD2 frizzled class receptor 2
FZD7 frizzled class receptor 7
GALC galactosylceramidase
GLRX glutaredoxin (thioltransferase)
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST3H2A histone cluster 3, H2a
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRSP12 heat-responsive protein 12
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INSM1 insulinoma-associated 1
KIAA0101 KIAA0101
KIAA0922 KIAA0922
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LEF1 lymphoid enhancer-binding factor 1
LGALS4 lectin, galactoside-binding, soluble, 4
LMNB1 lamin B1
LMO3 LIM domain only 3 (rhombotin-like 2)
LTBP1 latent transforming growth factor beta binding protein 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MN1 meningioma (disrupted in balanced translocation) 1
MTSS1 metastasis suppressor 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO10 myosin X
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OPN3 opsin 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PTCH1 patched 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SALL2 spalt-like transcription factor 2
SCG2 secretogranin II
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNN stannin
SOD3 superoxide dismutase 3, extracellular
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPINK4 serine peptidase inhibitor, Kazal type 4
SQLE squalene epoxidase
STMN1 stathmin 1
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR3 transforming growth factor, beta receptor III
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX thymocyte selection-associated high mobility group box
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TRMT5 tRNA methyltransferase 5
TST thiosulfate sulfurtransferase (rhodanese)
VCAM1 vascular cell adhesion molecule 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZHX2 zinc fingers and homeoboxes 2