BRD-A17065207_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-A17065207_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AGR2 anterior gradient 2
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL1 ADP-ribosylation factor-like 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BET1 Bet1 golgi vesicular membrane trafficking protein
BHLHE41 basic helix-loop-helix family, member e41
CALU calumenin
CARS cysteinyl-tRNA synthetase
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CHI3L2 chitinase 3-like 2
CKAP4 cytoskeleton-associated protein 4
CLDN1 claudin 1
CREB3L2 cAMP responsive element binding protein 3-like 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ESR1 estrogen receptor 1
FKBP10 FK506 binding protein 10, 65 kDa
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
GORASP2 golgi reassembly stacking protein 2, 55kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFRD1 interferon-related developmental regulator 1
ITM2A integral membrane protein 2A
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT7 keratin 7, type II
LRRC59 leucine rich repeat containing 59
MAGED1 melanoma antigen family D1
MANF mesencephalic astrocyte-derived neurotrophic factor
MIR22HG MIR22 host gene
MLEC malectin
MTDH metadherin
NANS N-acetylneuraminic acid synthase
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PDIA5 protein disulfide isomerase family A, member 5
PEG3 paternally expressed 3
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLAUR plasminogen activator, urokinase receptor
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRRC1 proline-rich coiled-coil 1
PSAT1 phosphoserine aminotransferase 1
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RGS1 regulator of G-protein signaling 1
RRBP1 ribosome binding protein 1
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SEC13 SEC13 homolog (S. cerevisiae)
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC61G Sec61 gamma subunit
SERP1 stress-associated endoplasmic reticulum protein 1
SFRP1 secreted frizzled-related protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35B1 solute carrier family 35, member B1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
TARS threonyl-tRNA synthetase
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TMED2 transmembrane emp24 domain trafficking protein 2
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM214 transmembrane protein 214
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRAM1 translocation associated membrane protein 1
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ANGPT1 angiopoietin 1
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CPE carboxypeptidase E
DENND1B DENN/MADD domain containing 1B
DPYSL2 dihydropyrimidinase-like 2
DUSP3 dual specificity phosphatase 3
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGL2 fibrinogen-like 2
FOXG1 forkhead box G1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSIG1 insulin induced gene 1
MAT2A methionine adenosyltransferase II, alpha
MECOM MDS1 and EVI1 complex locus
MTSS1 metastasis suppressor 1
NMU neuromedin U
NREP neuronal regeneration related protein
PDGFA platelet-derived growth factor alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAB29 RAB29, member RAS oncogene family
RCAN2 regulator of calcineurin 2
RTN1 reticulon 1
SDC1 syndecan 1
SHB Src homology 2 domain containing adaptor protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TMEM176B transmembrane protein 176B
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TUBB2A tubulin, beta 2A class IIa
ZFP36L2 ZFP36 ring finger protein-like 2