BRD-A17065207_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

440 genes differentially expressed following the BRD-A17065207_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
AHSP alpha hemoglobin stabilizing protein
AKAP17A A kinase (PRKA) anchor protein 17A
AKAP8 A kinase (PRKA) anchor protein 8
ARCN1 archain 1
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BET1 Bet1 golgi vesicular membrane trafficking protein
BHLHE41 basic helix-loop-helix family, member e41
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSDC1 BSD domain containing 1
CA1 carbonic anhydrase I
CALU calumenin
CCDC28A coiled-coil domain containing 28A
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCPG1 cell cycle progression 1
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHPF chondroitin polymerizing factor
CKAP4 cytoskeleton-associated protein 4
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COPA coatomer protein complex, subunit alpha
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DHDDS dehydrodolichyl diphosphate synthase
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELANE elastase, neutrophil expressed
ELL2 elongation factor, RNA polymerase II, 2
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
FKBP2 FK506 binding protein 2, 13kDa
FNDC3A fibronectin type III domain containing 3A
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GOLGA3 golgin A3
GOLGA5 golgin A5
GOLGB1 golgin B1
GOLT1B golgi transport 1B
GORASP2 golgi reassembly stacking protein 2, 55kDa
GTPBP2 GTP binding protein 2
HBD hemoglobin, delta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
ICAM3 intercellular adhesion molecule 3
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IFT20 intraflagellar transport 20
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM3A lysine (K)-specific demethylase 3A
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LCN2 lipocalin 2
LMAN1 lectin, mannose-binding, 1
LZTFL1 leucine zipper transcription factor-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MAGEH1 melanoma antigen family H1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MED8 mediator complex subunit 8
MIA3 melanoma inhibitory activity family, member 3
MIR22HG MIR22 host gene
MPC1 mitochondrial pyruvate carrier 1
MSLN mesothelin
MSN moesin
MUC4 mucin 4, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MYDGF myeloid-derived growth factor
NCAM1 neural cell adhesion molecule 1
NDEL1 nudE neurodevelopment protein 1-like 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUCB2 nucleobindin 2
OLFM4 olfactomedin 4
OSBPL2 oxysterol binding protein-like 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HB prolyl 4-hydroxylase, beta polypeptide
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM5 PDZ and LIM domain 5
PECAM1 platelet/endothelial cell adhesion molecule 1
PER2 period circadian clock 2
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PGM3 phosphoglucomutase 3
PHF1 PHD finger protein 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POFUT2 protein O-fucosyltransferase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PRRC1 proline-rich coiled-coil 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAB5A RAB5A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RBKS ribokinase
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC13 SEC13 homolog (S. cerevisiae)
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEC62 SEC62 homolog (S. cerevisiae)
SEC63 SEC63 homolog (S. cerevisiae)
SERINC1 serine incorporator 1
SERP1 stress-associated endoplasmic reticulum protein 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
SRP72 signal recognition particle 72kDa
SRPR signal recognition particle receptor (docking protein)
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SST somatostatin
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SUCO SUN domain containing ossification factor
TARS threonyl-tRNA synthetase
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TMEM39A transmembrane protein 39A
TMEM45A transmembrane protein 45A
TMEM87A transmembrane protein 87A
TRAM1 translocation associated membrane protein 1
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UFM1 ubiquitin-fold modifier 1
UQCRH ubiquinol-cytochrome c reductase hinge protein
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WBP5 WW domain binding protein 5
WDR45 WD repeat domain 45
WDR45B WD repeat domain 45B
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
YIPF3 Yip1 domain family, member 3
YIPF5 Yip1 domain family, member 5
YPEL5 yippee-like 5 (Drosophila)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZIC1 Zic family member 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AIM1 absent in melanoma 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
ANXA9 annexin A9
ARMT1 acidic residue methyltransferase 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
C3 complement component 3
CA12 carbonic anhydrase XII
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAND1 cullin-associated and neddylation-dissociated 1
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CD9 CD9 molecule
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHD3 chromodomain helicase DNA binding protein 3
CHRDL1 chordin-like 1
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COMMD8 COMM domain containing 8
CSE1L CSE1 chromosome segregation 1-like (yeast)
CST3 cystatin C
CSTA cystatin A (stefin A)
CTPS2 CTP synthase 2
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDB2 damage-specific DNA binding protein 2, 48kDa
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNA2 DNA replication helicase/nuclease 2
DSCC1 DNA replication and sister chromatid cohesion 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
EMP2 epithelial membrane protein 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
EVL Enah/Vasp-like
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FANCI Fanconi anemia, complementation group I
FASN fatty acid synthase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
FHL2 four and a half LIM domains 2
FOXA1 forkhead box A1
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS2L1 growth arrest-specific 2 like 1
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTM3 glutathione S-transferase mu 3 (brain)
GTSE1 G-2 and S-phase expressed 1
H1FX H1 histone family, member X
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXB6 homeobox B6
HOXC6 homeobox C6
HRSP12 heat-responsive protein 12
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGSF3 immunoglobulin superfamily, member 3
INSIG1 insulin induced gene 1
ISOC1 isochorismatase domain containing 1
ITGB5 integrin, beta 5
ITPK1 inositol-tetrakisphosphate 1-kinase
KIAA0101 KIAA0101
KIAA1467 KIAA1467
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LMNB2 lamin B2
LPL lipoprotein lipase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MCM10 minichromosome maintenance complex component 10
MEGF9 multiple EGF-like-domains 9
MGP matrix Gla protein
MLPH melanophilin
MREG melanoregulin
MRPS2 mitochondrial ribosomal protein S2
MSMB microseminoprotein, beta-
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYD88 myeloid differentiation primary response 88
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NINJ1 ninjurin 1
NIT2 nitrilase family, member 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OIP5 Opa interacting protein 5
OLFM1 olfactomedin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK1 polo-like kinase 1
PLS1 plastin 1
PLS3 plastin 3
PLXNA1 plexin A1
PLXNB2 plexin B2
PODXL podocalyxin-like
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPT1 palmitoyl-protein thioesterase 1
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
QDPR quinoid dihydropteridine reductase
RACGAP1 Rac GTPase activating protein 1
RAD51C RAD51 paralog C
RAD54B RAD54 homolog B (S. cerevisiae)
RET ret proto-oncogene
RGS10 regulator of G-protein signaling 10
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SCARB1 scavenger receptor class B, member 1
SCCPDH saccharopine dehydrogenase (putative)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SEPW1 selenoprotein W, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SET SET nuclear proto-oncogene
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFN stratifin
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC2A4RG SLC2A4 regulator
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF7 serine/arginine-rich splicing factor 7
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK26 serine/threonine protein kinase 26
STMN1 stathmin 1
SYBU syntabulin (syntaxin-interacting)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCL1A T-cell leukemia/lymphoma 1A
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMELESS timeless circadian clock
TM7SF2 transmembrane 7 superfamily member 2
TMEM106C transmembrane protein 106C
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM164 transmembrane protein 164
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIM14 tripartite motif containing 14
TRIP13 thyroid hormone receptor interactor 13
TRPS1 trichorhinophalangeal syndrome I
TSPAN4 tetraspanin 4
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZWINT ZW10 interacting kinetochore protein