BRD-A17065207_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

341 genes differentially expressed following the BRD-A17065207_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
AKAP17A A kinase (PRKA) anchor protein 17A
ARF4 ADP-ribosylation factor 4
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF6 activating transcription factor 6
ATG3 autophagy related 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BBX bobby sox homolog (Drosophila)
BTG3 BTG family, member 3
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COPA coatomer protein complex, subunit alpha
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTH cystathionine gamma-lyase
CXADR coxsackie virus and adenovirus receptor
CYB561 cytochrome b561
DAP death-associated protein
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPH2 DPH2 homolog (S. cerevisiae)
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EPRS glutamyl-prolyl-tRNA synthetase
FICD FIC domain containing
GOLT1B golgi transport 1B
GOT1 glutamic-oxaloacetic transaminase 1, soluble
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA13 heat shock protein 70kDa family, member 13
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB11 heat shock protein family B (small), member 11
ICAM3 intercellular adhesion molecule 3
IFT20 intraflagellar transport 20
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IQCG IQ motif containing G
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF5C kinesin family member 5C
KLHDC2 kelch domain containing 2
LCN2 lipocalin 2
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGEH1 melanoma antigen family H1
MALT1 MALT1 paracaspase
MANF mesencephalic astrocyte-derived neurotrophic factor
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MINA MYC induced nuclear antigen
MPC1 mitochondrial pyruvate carrier 1
MUC4 mucin 4, cell surface associated
MXI1 MAX interactor 1, dimerization protein
MZB1 marginal zone B and B1 cell-specific protein
NARS asparaginyl-tRNA synthetase
NEBL nebulette
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NME7 NME/NM23 family member 7
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
OLFM4 olfactomedin 4
OSBPL2 oxysterol binding protein-like 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCP4 Purkinje cell protein 4
PDZK1IP1 PDZK1 interacting protein 1
PER2 period circadian clock 2
PLXNC1 plexin C1
POU2AF1 POU class 2 associating factor 1
PPIE peptidylprolyl isomerase E (cyclophilin E)
PSIP1 PC4 and SFRS1 interacting protein 1
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
QPCT glutaminyl-peptide cyclotransferase
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBKS ribokinase
REG1A regenerating islet-derived 1 alpha
REXO2 RNA exonuclease 2
RIOK3 RIO kinase 3
RNF167 ring finger protein 167
RNMT RNA (guanine-7-) methyltransferase
RPS11 ribosomal protein S11
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SARAF store-operated calcium entry-associated regulatory factor
SARS seryl-tRNA synthetase
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC24A SEC24 family member A
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
SRPR signal recognition particle receptor (docking protein)
SRPRB signal recognition particle receptor, B subunit
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SULF1 sulfatase 1
TARS threonyl-tRNA synthetase
TERF2IP telomeric repeat binding factor 2, interacting protein
TM9SF2 transmembrane 9 superfamily member 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TSTA3 tissue specific transplantation antigen P35B
TXNL4B thioredoxin-like 4B
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
AOC3 amine oxidase, copper containing 3
AOX1 aldehyde oxidase 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BLVRA biliverdin reductase A
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C7 complement component 7
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC85B coiled-coil domain containing 85B
CCND1 cyclin D1
CD320 CD320 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CD69 CD69 molecule
CD9 CD9 molecule
CDC20 cell division cycle 20
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
COL4A2 collagen, type IV, alpha 2
COLEC12 collectin sub-family member 12
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYTL1 cytokine-like 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EBP emopamil binding protein (sterol isomerase)
ECM1 extracellular matrix protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELN elastin
EMP1 epithelial membrane protein 1
ENG endoglin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8 epidermal growth factor receptor pathway substrate 8
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS2 fatty acid desaturase 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM13A family with sequence similarity 13, member A
FAR2 fatty acyl CoA reductase 2
FASN fatty acid synthase
FAT1 FAT atypical cadherin 1
FBLN1 fibulin 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FERMT1 fermitin family member 1
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FST follistatin
FSTL1 follistatin-like 1
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GHR growth hormone receptor
GPC1 glypican 1
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HK1 hexokinase 1
HMGB1 high mobility group box 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRSP12 heat-responsive protein 12
HSPB1 heat shock 27kDa protein 1
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
ITGB5 integrin, beta 5
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KLF2 Kruppel-like factor 2
KRT19 keratin 19, type I
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LINC00341 long intergenic non-protein coding RNA 341
LOXL1 lysyl oxidase-like 1
LPL lipoprotein lipase
LY6E lymphocyte antigen 6 complex, locus E
MARCKSL1 MARCKS-like 1
MARCO macrophage receptor with collagenous structure
MBNL1 muscleblind-like splicing regulator 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1B myosin IB
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NT5E 5'-nucleotidase, ecto (CD73)
OPN3 opsin 3
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKM pyruvate kinase, muscle
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN1 perilipin 1
PLIN2 perilipin 2
PPARG peroxisome proliferator-activated receptor gamma
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
PYCARD PYD and CARD domain containing
PYGL phosphorylase, glycogen, liver
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHB Src homology 2 domain containing adaptor protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAGP small cell adhesion glycoprotein
SPRY4 sprouty homolog 4 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TAC1 tachykinin, precursor 1
TAGLN transgelin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM164 transmembrane protein 164
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TRAF3IP2 TRAF3 interacting protein 2
TRAM2 translocation associated membrane protein 2
TSPAN3 tetraspanin 3
TSPAN4 tetraspanin 4
TUBB6 tubulin, beta 6 class V
UGP2 UDP-glucose pyrophosphorylase 2
VCL vinculin
ZFP36L1 ZFP36 ring finger protein-like 1