BRD-A16998493_etodolac_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-A16998493_etodolac_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AMPD1 adenosine monophosphate deaminase 1
ARL4C ADP-ribosylation factor-like 4C
CA3 carbonic anhydrase III
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLC Charcot-Leyden crystal galectin
CLEC5A C-type lectin domain family 5, member A
CLIC3 chloride intracellular channel 3
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
DAPK1 death-associated protein kinase 1
DCN decorin
DLK1 delta-like 1 homolog (Drosophila)
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FOXF2 forkhead box F2
HBE1 hemoglobin, epsilon 1
HEBP2 heme binding protein 2
HEG1 heart development protein with EGF-like domains 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPB3 heat shock 27kDa protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
INA internexin neuronal intermediate filament protein, alpha
IPO13 importin 13
ITGA6 integrin, alpha 6
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1462 KIAA1462
KRT19 keratin 19, type I
LDB3 LIM domain binding 3
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MEIS2 Meis homeobox 2
MPZL2 myelin protein zero-like 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYRF myelin regulatory factor
NEB nebulin
NT5E 5'-nucleotidase, ecto (CD73)
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMP22 peripheral myelin protein 22
PON3 paraoxonase 3
PRTN3 proteinase 3
PVRL3 poliovirus receptor-related 3
RHOBTB1 Rho-related BTB domain containing 1
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SCD5 stearoyl-CoA desaturase 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SORBS2 sorbin and SH3 domain containing 2
SOX17 SRY (sex determining region Y)-box 17
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
SSPN sarcospan
SST somatostatin
SULF1 sulfatase 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRHDE thyrotropin-releasing hormone degrading enzyme
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TTN titin
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTN1 actinin, alpha 1
AKAP10 A kinase (PRKA) anchor protein 10
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
ASCC3 activating signal cointegrator 1 complex subunit 3
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CALML4 calmodulin-like 4
CAMLG calcium modulating ligand
CCL19 chemokine (C-C motif) ligand 19
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFDP1 craniofacial development protein 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHPT1 choline phosphotransferase 1
CTSH cathepsin H
CTSK cathepsin K
CTSL cathepsin L
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DARS aspartyl-tRNA synthetase
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DLD dihydrolipoamide dehydrogenase
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A3 eukaryotic translation initiation factor 4A3
EPRS glutamyl-prolyl-tRNA synthetase
ERBB3 erb-b2 receptor tyrosine kinase 3
F12 coagulation factor XII (Hageman factor)
FAM134B family with sequence similarity 134, member B
GGCT gamma-glutamylcyclotransferase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HLTF helicase-like transcription factor
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
ILK integrin-linked kinase
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO7 importin 7
IRF7 interferon regulatory factor 7
KIAA0101 KIAA0101
KIAA0226L KIAA0226-like
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTB lymphotoxin beta (TNF superfamily, member 3)
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MCUR1 mitochondrial calcium uniporter regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
MRFAP1L1 Morf4 family associated protein 1-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
NBN nibrin
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKTR natural killer cell triggering receptor
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOTCH2NL notch 2 N-terminal like
NPDC1 neural proliferation, differentiation and control, 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PHB prohibitin
PIP prolactin-induced protein
PKM pyruvate kinase, muscle
PPIF peptidylprolyl isomerase F
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCD protein kinase C, delta
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
RAB13 RAB13, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RNF167 ring finger protein 167
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPS27L ribosomal protein S27-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SEH1L SEH1-like (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLIRP SRA stem-loop interacting RNA binding protein
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SRSF11 serine/arginine-rich splicing factor 11
STOM stomatin
TALDO1 transaldolase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMED9 transmembrane emp24 protein transport domain containing 9
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TSPAN3 tetraspanin 3
TSPYL5 TSPY-like 5
TUSC3 tumor suppressor candidate 3
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WDR3 WD repeat domain 3
XBP1 X-box binding protein 1
XPO7 exportin 7
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8