BRD-A16820783_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-A16820783_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ADGRG6 adhesion G protein-coupled receptor G6
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA3 annexin A3
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
BMP6 bone morphogenetic protein 6
C3AR1 complement component 3a receptor 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK6 cyclin-dependent kinase 6
COL11A1 collagen, type XI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL4A1 collagen, type IV, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA4 defensin, alpha 4, corticostatin
DEFB1 defensin, beta 1
DGKZ diacylglycerol kinase, zeta
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
ELANE elastase, neutrophil expressed
F2RL1 coagulation factor II (thrombin) receptor-like 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLNA filamin A, alpha
FN1 fibronectin 1
FNBP1 formin binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6B glycoprotein M6B
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H3F3B H3 histone, family 3B (H3.3B)
HIP1R huntingtin interacting protein 1 related
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HOXB6 homeobox B6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
KRT17 keratin 17, type I
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGEA4 melanoma antigen family A4
MCOLN1 mucolipin 1
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MUC4 mucin 4, cell surface associated
MYRF myelin regulatory factor
OLFM4 olfactomedin 4
PFKP phosphofructokinase, platelet
PLK2 polo-like kinase 2
PSAT1 phosphoserine aminotransferase 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF144A ring finger protein 144A
S100A2 S100 calcium binding protein A2
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TPM2 tropomyosin 2 (beta)
VAT1 vesicle amine transport 1
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT1
C14ORF1 chromosome 14 open reading frame 1
C1S complement component 1, s subcomponent
CA2 carbonic anhydrase II
CCL19 chemokine (C-C motif) ligand 19
CCNE2 cyclin E2
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPT dermatopontin
DPYD dihydropyrimidine dehydrogenase
EAPP E2F-associated phosphoprotein
EIF5 eukaryotic translation initiation factor 5
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FEN1 flap structure-specific endonuclease 1
GFRA1 GDNF family receptor alpha 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLUL glutamate-ammonia ligase
HADH hydroxyacyl-CoA dehydrogenase
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
KAT6B K(lysine) acetyltransferase 6B
KIAA0485 uncharacterized LOC57235
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYZ lysozyme
MAP7 microtubule-associated protein 7
MED21 mediator complex subunit 21
MELK maternal embryonic leucine zipper kinase
MREG melanoregulin
MSH6 mutS homolog 6
NUPR1 nuclear protein, transcriptional regulator, 1
PCNA proliferating cell nuclear antigen
PITX1 paired-like homeodomain 1
PRKCD protein kinase C, delta
PSPH phosphoserine phosphatase
RFC2 replication factor C (activator 1) 2, 40kDa
RMI1 RecQ mediated genome instability 1
RNASE4 ribonuclease, RNase A family, 4
RNF167 ring finger protein 167
SELT selenoprotein T
SEPP1 selenoprotein P, plasma, 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
TCF4 transcription factor 4
TFF3 trefoil factor 3 (intestinal)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOR1AIP1 torsin A interacting protein 1
TPBG trophoblast glycoprotein
TSPAN6 tetraspanin 6
UBE2A ubiquitin-conjugating enzyme E2A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGCG UDP-glucose ceramide glucosyltransferase
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein