BRD-A16820783_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-A16820783_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRL2 adhesion G protein-coupled receptor L2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
CD47 CD47 molecule
CD9 CD9 molecule
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ENAH enabled homolog (Drosophila)
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM3C family with sequence similarity 3, member C
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FXYD6 FXYD domain containing ion transport regulator 6
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
HDAC9 histone deacetylase 9
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFT57 intraflagellar transport 57
IGL immunoglobulin lambda locus
JAG1 jagged 1
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MMP7 matrix metallopeptidase 7
MOXD1 monooxygenase, DBH-like 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NCAM1 neural cell adhesion molecule 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRR7 proline rich 7 (synaptic)
PTN pleiotrophin
REEP5 receptor accessory protein 5
RHOB ras homolog family member B
RIPK4 receptor-interacting serine-threonine kinase 4
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN2 transgelin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TUBA1A tubulin, alpha 1a
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
WFDC2 WAP four-disulfide core domain 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FTH1 ferritin, heavy polypeptide 1
GAS1 growth arrest-specific 1
GRB14 growth factor receptor-bound protein 14
HBD hemoglobin, delta
HIST1H2BG histone cluster 1, H2bg
HOXC6 homeobox C6
IFITM1 interferon induced transmembrane protein 1
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP9 matrix metallopeptidase 9
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYRF myelin regulatory factor
NDRG2 NDRG family member 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NPR3 natriuretic peptide receptor 3
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCCB propionyl CoA carboxylase, beta polypeptide
PCSK6 proprotein convertase subtilisin/kexin type 6
PLXND1 plexin D1
PRKCB protein kinase C, beta
PRKCH protein kinase C, eta
QPRT quinolinate phosphoribosyltransferase
RAD23B RAD23 homolog B (S. cerevisiae)
RHOBTB3 Rho-related BTB domain containing 3
RXRA retinoid X receptor, alpha
S100P S100 calcium binding protein P
SELL selectin L
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TFF1 trefoil factor 1
THY1 Thy-1 cell surface antigen
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
WFS1 Wolfram syndrome 1 (wolframin)
ZC3H13 zinc finger CCCH-type containing 13
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF318 zinc finger protein 318