BRD-A16700644_ISOXSUPRINE HYDROCHLORIDE_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-A16700644_ISOXSUPRINE HYDROCHLORIDE_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA1 actin, alpha 1, skeletal muscle
ADIRF adipogenesis regulatory factor
ALB albumin
AREG amphiregulin
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAV1 caveolin 1, caveolae protein, 22kDa
CD40 CD40 molecule, TNF receptor superfamily member 5
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL9 chemokine (C-X-C motif) ligand 9
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FAM69A family with sequence similarity 69, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FST follistatin
FTH1 ferritin, heavy polypeptide 1
HIST1H4C histone cluster 1, H4c
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IGL immunoglobulin lambda locus
LYZ lysozyme
MAOB monoamine oxidase B
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYBPC1 myosin binding protein C, slow type
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NEB nebulin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMU neuromedin U
P3H2 prolyl 3-hydroxylase 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLN sarcolipin
SOCS2 suppressor of cytokine signaling 2
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TTN titin
TXNIP thioredoxin interacting protein
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
BPIFA1 BPI fold containing family A, member 1
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
NEFL neurofilament, light polypeptide
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PRSS23 protease, serine, 23
RHOB ras homolog family member B
RNF11 ring finger protein 11
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SLPI secretory leukocyte peptidase inhibitor
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TGM2 transglutaminase 2