BRD-A15931911_BUCLADESINE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-A15931911_BUCLADESINE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AQP1 aquaporin 1 (Colton blood group)
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
CPM carboxypeptidase M
EFHC2 EF-hand domain (C-terminal) containing 2
EFS embryonal Fyn-associated substrate
FGB fibrinogen beta chain
FOXO1 forkhead box O1
GAGE3 G antigen 3
GATA3 GATA binding protein 3
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
KIAA0125 KIAA0125
LPIN2 lipin 2
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METTL21B methyltransferase like 21B
PEG3 paternally expressed 3
PLTP phospholipid transfer protein
RGS1 regulator of G-protein signaling 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SH2D1A SH2 domain containing 1A
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TDO2 tryptophan 2,3-dioxygenase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TRPS1 trichorhinophalangeal syndrome I
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UPK1B uroplakin 1B
VCAN versican
ZNF331 zinc finger protein 331
ZNF432 zinc finger protein 432
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADORA2B adenosine A2b receptor
AK2 adenylate kinase 2
ANXA3 annexin A3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
C2CD5 C2 calcium-dependent domain containing 5
C3ORF14 chromosome 3 open reading frame 14
CANT1 calcium activated nucleotidase 1
CCL2 chemokine (C-C motif) ligand 2
CD320 CD320 molecule
CD47 CD47 molecule
CD58 CD58 molecule
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDKN3 cyclin-dependent kinase inhibitor 3
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLDN3 claudin 3
CLTB clathrin, light chain B
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COG2 component of oligomeric golgi complex 2
COTL1 coactosin-like F-actin binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
DCK deoxycytidine kinase
DERA deoxyribose-phosphate aldolase (putative)
DPYSL2 dihydropyrimidinase-like 2
DUSP3 dual specificity phosphatase 3
EFHD2 EF-hand domain family, member D2
EIF5 eukaryotic translation initiation factor 5
EMC8 ER membrane protein complex subunit 8
ENO1 enolase 1, (alpha)
EPN2 epsin 2
EXT1 exostosin glycosyltransferase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBXO21 F-box protein 21
FN1 fibronectin 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB7 growth factor receptor-bound protein 7
GSTZ1 glutathione S-transferase zeta 1
HAT1 histone acetyltransferase 1
HIST1H2BK histone cluster 1, H2bk
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFRD2 interferon-related developmental regulator 2
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
KDM3A lysine (K)-specific demethylase 3A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT8 keratin 8, type II
LAP3 leucine aminopeptidase 3
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LOXL2 lysyl oxidase-like 2
LYPLA1 lysophospholipase I
MAPK13 mitogen-activated protein kinase 13
MFSD10 major facilitator superfamily domain containing 10
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTX2 metaxin 2
MYO1B myosin IB
NOP16 NOP16 nucleolar protein
NPTX2 neuronal pentraxin II
NRIP1 nuclear receptor interacting protein 1
PAM peptidylglycine alpha-amidating monooxygenase
PAWR PRKC, apoptosis, WT1, regulator
PDZK1IP1 PDZK1 interacting protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
PON2 paraoxonase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPT1 palmitoyl-protein thioesterase 1
PROM1 prominin 1
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTTG1 pituitary tumor-transforming 1
PWP1 PWP1 homolog (S. cerevisiae)
PXDN peroxidasin
RAB5C RAB5C, member RAS oncogene family
RHOB ras homolog family member B
RNH1 ribonuclease/angiogenin inhibitor 1
RPA3 replication protein A3, 14kDa
RPIA ribose 5-phosphate isomerase A
S100A10 S100 calcium binding protein A10
SAMD4A sterile alpha motif domain containing 4A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TOM1L1 target of myb1 (chicken)-like 1
TPBG trophoblast glycoprotein
TRAPPC3 trafficking protein particle complex 3
TRIM14 tripartite motif containing 14
TRIP6 thyroid hormone receptor interactor 6
TUBB6 tubulin, beta 6 class V
UBE2S ubiquitin-conjugating enzyme E2S
UFM1 ubiquitin-fold modifier 1
VAT1 vesicle amine transport 1
WARS tryptophanyl-tRNA synthetase
WWC1 WW and C2 domain containing 1
YBX3 Y box binding protein 3
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YY1 YY1 transcription factor
ZC3H15 zinc finger CCCH-type containing 15