BRD-A15914070_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-A15914070_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
AOX1 aldehyde oxidase 1
CD163 CD163 molecule
CRYAB crystallin, alpha B
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DENND1B DENN/MADD domain containing 1B
DUSP5 dual specificity phosphatase 5
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
FAM46A family with sequence similarity 46, member A
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GPI glucose-6-phosphate isomerase
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KDM5D lysine (K)-specific demethylase 5D
KDSR 3-ketodihydrosphingosine reductase
KLF4 Kruppel-like factor 4 (gut)
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
MAP2K3 mitogen-activated protein kinase kinase 3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
MPO myeloperoxidase
NQO1 NAD(P)H dehydrogenase, quinone 1
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RAD23B RAD23 homolog B (S. cerevisiae)
RHOBTB3 Rho-related BTB domain containing 3
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ANXA3 annexin A3
CYR61 cysteine-rich, angiogenic inducer, 61
DENND2D DENN/MADD domain containing 2D
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EVI2A ecotropic viral integration site 2A
FBP1 fructose-1,6-bisphosphatase 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
H2AFV H2A histone family, member V
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MECOM MDS1 and EVI1 complex locus
MLPH melanophilin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PEG10 paternally expressed 10
POU2AF1 POU class 2 associating factor 1
PRKCD protein kinase C, delta
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TMSB15A thymosin beta 15a
TNS3 tensin 3
TSC22D3 TSC22 domain family, member 3
VIM vimentin