BRD-A15914070_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-A15914070_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ANKMY2 ankyrin repeat and MYND domain containing 2
BAG3 BCL2-associated athanogene 3
BLVRB biliverdin reductase B
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CD163 CD163 molecule
CD52 CD52 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CTSL cathepsin L
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK5 docking protein 5
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GLRX glutaredoxin (thioltransferase)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP2 lysosomal-associated membrane protein 2
LY96 lymphocyte antigen 96
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
NCOA3 nuclear receptor coactivator 3
NQO1 NAD(P)H dehydrogenase, quinone 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIR pirin (iron-binding nuclear protein)
RAP2B RAP2B, member of RAS oncogene family
S100A9 S100 calcium binding protein A9
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SQSTM1 sequestosome 1
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNNT1 troponin T type 1 (skeletal, slow)
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFD1L ubiquitin fusion degradation 1 like (yeast)

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADGRE5 adhesion G protein-coupled receptor E5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CCND1 cyclin D1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
COL9A3 collagen, type IX, alpha 3
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
EDNRA endothelin receptor type A
EPHA3 EPH receptor A3
FLRT3 fibronectin leucine rich transmembrane protein 3
G0S2 G0/G1 switch 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
ITGA6 integrin, alpha 6
LAMB1 laminin, beta 1
LAMC2 laminin, gamma 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
NFIB nuclear factor I/B
PALLD palladin, cytoskeletal associated protein
PLAT plasminogen activator, tissue
PMEPA1 prostate transmembrane protein, androgen induced 1
PPA1 pyrophosphatase (inorganic) 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PSIP1 PC4 and SFRS1 interacting protein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
QDPR quinoid dihydropteridine reductase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
SERBP1 SERPINE1 mRNA binding protein 1
STX1A syntaxin 1A (brain)
TMEM2 transmembrane protein 2
TNC tenascin C
TUBB2B tubulin, beta 2B class IIb
WSB2 WD repeat and SOCS box containing 2